With increasing age, there is chance of developing different chronic conditions which are often accompanied by use multiple medicines that can lead to polypharmacy be defined as five or more medicine include the one has been prescribed, over counter (OTC) well complementary medicine. Geriatric people particularly those with co-morbid health conditions, may develop high risk Adverse Drug Events ...

Drug Screening In article number 2207194, Mengsu Yang and co-workers design a high throughput microfluidic chip that could achieve multi-function drug screening against collective migration of cancer cells under confined environment. Using this device, three new compounds significantly inhibit are found: MA-5, SB-705498 diphenyleneiodonium chloride (DPI). These target mitochondria, actin polyme...

An alternative in vitro approach to drug screening has been the use of human cell cultures for antiviral agents and microbial cell cultures for the assessment of the carcinogenic potential of selected compounds. A number of protozoan species have been also used as drug screens for anti-protozoal agents. The ciliated protozoan Tetrahymena pyriformis species has been widely utilised as a dru...

Introduction A drug interaction occurs when one drug alters the pharmacological effect (enhanced or decreased) of another drug. In human medicine there are several resources available to screen for drug interactions, and there are specific guidelines and agencies to report suspected drug interactions to. In veterinary medicine screening, monitoring, and reporting of drug interactions are rarely...

BACKGROUND Screening, brief intervention, and referral to treatment (SBIRT) approaches to reducing hazardous alcohol and illicit drug use have been assessed in a variety of health care settings, including primary care, trauma centers, and emergency departments. A major methodological concern in these trials, however, is "assessment reactivity," the hypothesized impact of intensive research asse...

Background:                             The use of new technologies in the field of drug discovery and development plays an important role in introducing new and effective drugs, optimizing the properties of existing drugs and, in general the development of various drug-dependent industries, as well as the general health of human, animal and plant communities. These methods provide new drugs at...

BACKGROUND In England and Wales where less than 1% of the population are Injecting drug users (IDUs), 97% of HCV reports are attributed to injecting drug use. As over 60% of the IDU population will have been imprisoned by the age of 30 years, prison may provide a good location in which to offer HCV screening and treatment. The aim of this work is to examine the cost effectiveness of a number of...

The use of drugs other than alcohol is a leading cause of fatal injury in the United States, accounting for more than 40 000 deathsperyear.1 Increases intherateofdrug-attributabledeaths over the past 2 decades have beenfueledbyoverdosesof illicitlyusedprescriptiondrugs (such as opioids and sedatives, sometimes in combination with alcohol). In 2011, an estimated 1 280 134 hospitalizations were r...

Fragment-based drug discovery (FBDD) concerns the screening of low-molecular weight compounds against macromolecular targets of clinical relevance. These compounds act as starting points for the development of drugs. FBDD has evolved and grown in popularity over the past 15 years. In this paper, the rationale and technology behind the use of X-ray crystallography in fragment based screening (FB...

INTRODUCTION Prescription-drug use in the USA has increased by more than 60% in the last three decades. Prevalence of prescription-drug use among pregnant women is currently estimated around 50%. Prevalence of illicit drug use in the USA is 14.6% among pregnant adolescents, 8.6% among pregnant young adults and 3.2% among pregnant adults. The first step in identifying problematic drug use during...