In-silico Computer-Aided Drug Design (CADD) significantly relies on cybernetic screening of Plant Based Natural Products (PBNPs) as a prime source bioactive compounds/ drug leads due to their unique chemical structural scaffolds and distinct functional characteristic features amenable design development. In the Post-COVID-Era large number publications have focused PBNPs. Moreover, PBNPs still r...

Chiral diamine-derived hydrogen-bond donors were evaluated for their ability to effect stereocontrol in an intramolecular hetero-Diels-Alder (HDA) reaction hypothesized in the biosynthesis of brevianamides A and B. Collectively, these results provide proof of principle that small-molecule hydrogen-bond catalysis, if even based on a hypothetical biosynthesis construct, holds significant potentia...

In the course of screening natural products for antibacterial activities, a total acetone extract of the seed cake of Paeonia rockii showed significant effects against bacterial strains. Bioactivity-guided fractionation of the EtOAc-soluble fraction of the total acetone extract resulted in the isolation and identification of five resveratrol trimers, including rockiiol C (1), gnetin H (2), suff...

The importance of natural products in therapeutics has been generally recognized from immemorial time. The Amerindians' knowledge of hallucinogenic plants used for their religious rituals, as well as the aphrodisiac properties of several potions prepared from several plant species, have accompanied man for millennia. Throughout the ages, the search for the well-being and for the pleasure has al...

Cancer chemotherapeutic drugs acts in different manner to kill malignant cells. Most of the anticancer available clinical practice treat cancer patients, are natural products including whole plant extract, crude extracts, isolated constituents, –based drug formulations etc. These compounds have been a basis for development several against cancer. Agents such as topotecan, taxol, vinca alkaloids...