Drugs may be given by different routes in order to exert systemic or local effect. From the pharmacokinetics point of view, considering muscles as body compartment, it is important to characterize absorption after intramuscular (IM) drug administration, and drug distribution into muscle following drug administration. IM injection is characterized by invasive procedure puncturing the skin with a...

Purified serum cholinesterase 90 mg was administered to a patient with cholinesterase deficiency. The effect on the action of suxamethonium was studied. The half-life (44.7 h), time constant (64.5 h), rate constant (0.0155 h-1) and distribution volume (2740 ml) of the cholinesterase activity were determined.

A sensitive, precise microbiological assay has been developed for the determination of tissue distribution of 5-diazouracil, a potential antitumor and antimicrobial agent.

1Grupo Sistemas de Liberación Modificada de Moléculas Biológicamente Activas, Departamento de Farmacia, Universidad Nacional de Colombia, Bogotá, Colombia, 2Grupo de Análise e Desenvolvimento de Fármacos de Origem Natural, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina UFSC, SC, Florianópolis, Brasil,3Grupo de Estudio y Aprovechamiento de Productos Naturales Mari...

Carbon-11-raclopride has been successfully utilized with PET to assess changes in endogenous dopamine concentration after pharmacological intervention in the living baboon brain. For similar studies to be done in humans, measurements of 11C-raclopride with no intervention need to be reproducible. In order to test the reproducibility (test-retest) of 11C-raclopride binding in the human brain, we...

OBJECTIVE The present study was undertaken to investigate the pharmacokinetics of metronidazole in pregnant patients with bacterial vaginosis. METHODS Twenty patients received metronidazole (Flagyl ®, Pfizer, 235 East 42nd Street, NY, NY 10017) oral dose 500 mg twice a day for 3 consecutive days. Pharmacokinetic analyses of metronidazole were performed after a single oral dose on the morning ...

Defining adequacy of dialysis remains an elusive goal. The application of the Kt/Vurea concept to clinical dialysis was a major improvement in trying to define a dialysis dose. Intuitively, the Kt/V concept makes a great deal of sense: the urea clearance of the dialyzer during dialysis (K), multiplied by the time (t) of dialysis, divided by the patient's urea distribution volume (V) ought to gi...

A sensitive, precise microbiological assay was developed for the determination of tissue distribution of dl-alanosine, a new antitumor agent.

* Correspondence: [email protected]

1. Two-hundred and forty duplicate estimations of physiological dead-space volume ( VD) were made in forty-eight healthy subjects (twenty-four men and twenty-four women) aged from 20 to 74 years, to assess the predictive accuracy of various standards. 2. The V,/ VT (physiological dead-space volume/tidal volume) ratio standard was least precise, but could be improved by allowing for sex and age....