SUMMARY Rapid advances in pharmaceutical sciences have brought ever-increasing interests in combined therapies for better clinical efficacy and safety, especially in cases of complicated and refractory diseases. Innovative experimental technologies and theoretical frameworks are being actively developed for multicomponent drug research. In this work, we present the Drug Combination Database, wi...

Lyme disease is a most common vector-borne disease in the US. Although the majority of Lyme patients can be cured with the standard two- to four-week antibiotic treatment, at least 10%-20% of patients continue to suffer from prolonged post-treatment Lyme disease syndrome (PTLDS). While the cause for this is unclear, one possibility is that persisting organisms are not killed by current Lyme ant...

Drug combination is becoming a popular strategy for combating complex traits, where combination of drugs improves therapy significantly over single agents. However, it is a challenging task to identify the optimal and effective combinations of drugs due to explosion of huge number of possible combinations among drugs. Therefore, it is necessary to understand the mechanisms underlying drug combi...