introduction: for thousands of years, plants have been used as the main source of drug worldwide. recently, it has been found out that the plant artemisia annua and especially its derivatives such as artemether have anticancer properties. methods: in this study, the anticancer effect of artemether on mcf-7 breast cancer cell line was examined. mtt assay was used to assess the viability of cance...

user-generated medical messages on internet contain extensive information related to adverse drug reactions (adrs) and are known as valuable resources for post-marketing drug surveillance. the aim of this study was to find an effective method to identify messages related to adrs automatically from online user reviews.we conducted experiments on online user reviews using different feature set an...

Combination chemotherapy and nanoparticle drug delivery are two areas that have shown significant promise in cancer treatment. Combined therapy of two or more drugs promotes synergism among the different drugs against cancer cells and suppresses drug resistance through distinct mechanisms of action. Nanoparticle drug delivery, on the other hand, enhances therapeutic effectiveness and reduces si...

Drug resistance, de novo and acquired, pervades cellular signaling networks (SNs) from one signaling motif to another as a result of cancer progression and/or drug intervention. This resistance is one of the key determinants of efficacy in targeted anti-cancer drug therapy. Although poorly understood, drug resistance is already being addressed in combination therapy by selecting drug targets wh...

abstract introduction & objective: enuresis is defined as involuntary voiding. it is a socially disruptive and stressful condition which affects around 15% of five years old children and up to 1% of adults. aim the aim of this study was to assess the efficacy of desmopressin (nasal spray) and oxybutinin combination therapy in treatment of patients with primary nocturnal enuresis that were resis...