Amongst various carriers explored for target oriented drug delivery, vesicular, microparticulate and cellular carriers meet several criteria rendering them useful in clinical applications. Lymphocytes, leukocytes, platelets, granulocytes and erythrocytes have been proposed as a cellular carrier. Erythrocytes, also known as red blood cells, and have been the most extensively investigated and fou...

In this work three capsule-based dry powder inhalers, available for generics product development, were compared. Two technologically different dry powder formulations were used in order to relate the capsule piercing position and motion in the device to their aerodynamic performance. A "pierce and inhale" design, in which the capsules pierced with RS01, HandiHaler or Turbospin devices were aero...

In the presented work, amphiphilic nanoparticles based on chitosan and carboxy-enriched polylactic acid have been prepared to improve the stability of the pro-drug temozolomide in physiological media by encapsulation. The carrier, with a diameter in the range of 150-180 nm, was able to accommodate up to 800 μg of temozolomide per mg of polymer. The obtained formulation showed good stability in ...

Niosomes are considered as novel nano-carrier in the drug delivery systems. These much more stable than other nano-carriers like liposomes and nanoparticles. It is an example for targeted control release of medication. The entrapped into lipid core so that it prevents from leaching. Here will be only to desired cell/tissue not non-targeted cells. By giving this formulation we can thereby reduce...

Background: Preliminary safety evaluation of polymer intended to use as drug delivery carrier is essential. Methods: In this study polyacrylamide grafted bacterial cellulose (BC/AM) hydrogel was prepared by microwave irradiation initiated free radical polymerization. The synthesized hydrogel was subjected to in vitro cytotoxicity and acute gastrointestinal toxicity studies to evaluate its biolo...

In the present study, an attempt was made to increase the in vitro dissolution rate of carvedilol (antihypertensive) by cogrinding technique using various carriers, namely lactose, corn starch, treated agar, microcrystalline cellulose. The coground mixtures were prepared using the above excipients in four drug-carrier ratios, viz., 1:1, 1:3, 1:4 and 1:9. The prepared coground mixtures were eval...

The aim of the present study was to increase the solubility of a poorly water soluble BCS class II drug, valsartan. Liquisolid technology and solid dispersion by kneading method were techniques used to improve the solubility of the drug by using non-volatile solvents and some hydrophilic carriers. Liquisolid compacts were prepared by dissolving the drug in suitable non volatile solvents. The va...