We found that c-kit-positive, lineage marker-negative, Thy-1lo cells are present in both bone marrow and thymus ("BM c-kit" and "thymus c-kit" cells). Although the two cell types are phenotypically similar, only BM c-kit cells showed the potential to form colonies in vitro as well as in vivo. However, both of them revealed extensive growth and differentiation potential to T cells after direct t...

PURPOSE KIT (CD117) is a transmembrane tyrosine kinase representing a target for STI571 (Glivec) therapy. Some KIT-overexpressing solid tumors have responded favorably to STI571, potentially because of the presence of KIT-activating mutations. EXPERIMENTAL DESIGN To investigate the epidemiology of KIT overexpression and mutations, we investigated a series of 1654 breast cancers. All tumors we...

c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the concept that inhibiting c-Kit kinase activity can be a target for cancer therapy. The promising results of inhibition of c-Kit for treatment of cancers have been observed in some cancers such as gastroin...

OBJECTIVES To assess whether the commercial ViroSeq HIV-1 Genotyping System (Abbott Molecular, Des Plains, IL, USA) can be used in conjunction with dried blood spots (DBS) for clinical monitoring of drug resistance in patients who fail antiretroviral treatment (ART) in rural Tanzania. PATIENTS AND METHODS Patients at Haydom Lutheran Hospital with confirmed treatment failure (viral load >1000 ...

The c-kit protein plays a major role in the regulation of germ cell development. Its expression and distribution in rodent testes have been widely reported. However, research regarding c-kit expression in domestic animals is scarce, and the expression pattern and distribution of c-kit in germ cells have not been clearly defined. In this study, a specific antigenic region for goat c-kit was desi...

Inorganic arsenic (iAs) in 13 store-bought edible seaweed samples and 34 dried kelp (Laminaria digitata) samples was determined by a newly developed, field-deployable method (FDM) with the aid of a field test kit for arsenic in water. Results from the FDM were compared to results from speciation analysis achieved by using high performance liquid chromatography coupled to inductively coupled pla...

1. Abstract 2. Introduction 3. SCF, Kit and the PI3 kinase pathway 3.1. Kit and Kit ligand SCF 3.2. PI3 kinase 3.3. Akt and its activation 3.4. The FOXO subclass of forkhead box transcription factors 4. Kit-PI3 kinase signaling in mammalian oocytes 4.1. Kit and SCF in the mammalian ovary 4.2. Activation of the oocyte PI3 kinase pathway in mouse and rat oocytes by SCF 5. Mutant mouse models for ...

Background: Dried fruit is one of the main sources of sulphur dioxide (SO2) exposure. The major goal of the current study was to determine SO2 concentration in some widely consumed dried fruits in Hamadan, Iran. In addition, an estimate of sulphite intake was made through the aforementioned dried fruit. Methods: Totally, 126 dried fruit samples were randomly collected from local market in Hama...