Background Host genetic factors are the major determining factor for variation in response to HIV infection and are related to resistance among HIV patients. HLA dRB1*1501, DRB1*1502, DRB1*1301, DRB1*1302, DRB1*1101-05 are widely reported alleles associated with low viraemia in infected individuals. Computational predictions have made it possible to identify potentially strong peptide binders t...

Pemphigus Vulgaris (PV) has one of the strongest known HLA disease associations. The majority PV patients studied carry either DRB1*0402 or DQB1*0503. However, studies on associations in have largely focused populations with specific ethnic backgrounds, often Ashkenazi Jewish (AJ) and non-Jewish Caucasians there are limited African descent. We investigated status 11 American (AA) comparison to ...

OBJECTIVES To elucidate the contribution of HLA-DR-DQ haplotypes and their genotypic combinations to susceptibility to rheumatoid arthritis, and to evaluate the various models for HLA associated risk for the disease in a series of Finnish patients. METHODS 322 Finnish patients with rheumatoid arthritis were typed for common north European HLA-DR-DQ haplotypes and compared with a series of 124...

OBJECTIVE To assess the role of HLA polymorphism in the susceptibility to tuberculosis in Syria. METHODS We used the polymerase chain reaction with sequence specific primer method to study the DRB1* locus in 147 Syrian patients with positive sputum smear or sputum culture for Mycobacterium Tuberculosis strains, and 209 Syrian healthy matching individuals with negative tuberculin skin test. Pa...

BACKGROUND Nationwide surveys conducted in Japan over the past thirty years have revealed a four-fold increase in the estimated number of multiple sclerosis (MS) patients, a decrease in the age at onset, and successive increases in patients with conventional MS, which shows an involvement of multiple sites in the central nervous system, including the cerebrum and cerebellum. We aimed to clarify...

The primary associations of the HLA class II genes, HLA-DRB1 and HLA-DQB1, and the class I genes, HLA-A and HLA-B, with type 1 diabetes (T1D) are well established. However, the role of polymorphism at the HLA-DRB3, HLA-DRB4, and HLA-DRB5 loci remains unclear. In two separate studies, one of 500 subjects and 500 control subjects and one of 366 DRB1*03:01-positive samples from selected multiplex ...

We studied the frequencies of human leukocyte antigen alleles (A, B, and DRB1) in 90 patients with acute lymphoblastic leukemia (ALL) and then compared them with 126 controls in this study. Although the frequencies of the A*03 allele, the DRB1*03 allele, the DRB1*04 allele, the A*02/B*35/DRB1*13 haplotype, and homozygosity of A*02 were higher in patients (p=0.006, p=0.003, p=0.002, p=0.01, and ...

BACKGROUND HLA-DRB1 allele polymorphisms have been reported to be associated with hepatocellular carcinoma susceptibility, but the results of these previous studies have been inconsistent. The purpose of the present study was to explore whether specific HLA-DRB1 alleles (DRB1*07, DRB1*12, DRB1*15) confer susceptibility to hepatocellular carcinoma. METHODS Case-control studies on HLA-DRB1 alle...

testing revealed that the patient was positive for HLA-DRB1*04, HLA-DRB1*12, HLA-DQB1*03, andHLA-DQB1*04. To best of our knowledge, this is first case fulminant T1DM reported to occurimmediately after COVID-19 infection.

Amaç: Bu çalışmada, Sağlık Araştırma ve Uygulama Merkezi Doku Tipleme Laboratuvarına başvuran kişilerde HLA sınıf I II allel sıklığının belirlenmesi genotipleme sonuçlarının değerlendirilmesi amaçlanmıştır. Gereç yöntem: Çalışmamızda toplam 1903 kişinin verileri incelenmiş sıklığı hesaplanmıştır. A, B DRB1 allelleri tüm örneklerde, C DQB1 alleleri 493 kişide çalışılmıştır. Değerlendirmeye alınm...