Since the first determination of structure of the HLA-A2 complex, >200 MHC/peptide structures have been recorded, whereas the available T cell receptor (TCR)/peptide/MHC complex structures now are <20. Among these structures, only six are TCR/peptide/MHC Class II (MHCII) structures. The most recent of these structures, obtained by using TCR-Ob.1A12 from a multiple sclerosis patient and the MBP8...

BACKGROUND Susceptibility to inflammatory bowel disease (IBD) is partially genetically determined and the HLA class II genes are candidates for a role in genetic susceptibility to IBD, because their products play a central role in the immune response. Multiple studies have reported associations between HLA-DR or -DQ phenotypes and either ulcerative colitis or Crohn's disease, but much of the da...

Inspired by the work of Mirollo and Vilonen [MV] describing the categories of perverse sheaves as module categories over certain finite dimensional algebras, Dlab and Ringel introduced [DR2] an explicit recursive construction of these algebras in terms of the algebras A(γ). In particular, they characterized the quasi-hereditary algebras of Cline-Parshall-Scott [PS] and constructed them in this ...