Antioxidants have been reported to be effective in reducing acoustic trauma in animal models but have not been studied in humans. In this study, the antioxidant N-acetylcysteine (NAC) was evaluated to determine if it would reduce temporary changes in auditory function as a result of exposure to loud music in humans. Pure-tone thresholds and distortion product otoacoustic emissions (DPOAEs) were...

Materials and Methods: Twenty-five patients (50 ears) with acne vulgaris who were treated with isotretinoin 5mg/kg were included in this study. Two patients gave up using isotretinoin after two months. Pure tone audiometry, TEOAE and DPOAE were evaluated before the use of isotretinoin and after 4 months of treatment. DPOAE was recorded as a DPgram. Results: Pre-treatment and post-treatment pure...

Dominant mutations of transmembrane channel-like gene 1 (TMC1) cause progressive sensorineural hearing loss in humans and Beethoven (Tmc1Bth/+) mice. Here we show that Tmc1Bth/+ mice on a C3HeB/FeJ strain background have selective degeneration of inner hair cells while outer hair cells remain structurally and functionally intact. Inner hair cells primarily function as afferent sensory cells, wh...

BACKGROUND Developmental exposure to polychlorinated biphenyls (PCBs) or methylmercury (MeHg) can result in a variety of neurotoxic effects, including long-term auditory deficits. However, little is known about the effects of combined exposure to PCBs and MeHg on auditory function. OBJECTIVE We developmentally exposed rats to PCBs and/or MeHg and assessed auditory function in adulthood to det...

This study examined the effect of three different body positions on distortion-product otoacoustic emission (DPOAE) amplitude and noise levels with multiple primary tone pairs simultaneously-presented to 36 normal-hearing female human adults. Other studies have demonstrated that the simultaneously presented tone pairs method shows clinical promise as a screener, but the sequential method remain...

BACKGROUND Audiological evaluation of parents of individuals with autosomal recessive hearing loss. AIM To study the audiological profile of parents of individuals with autosomal recessive hearing loss, inferred by family history or by molecular tests that detected heterozygous mutations in the GJB2 gene. This gene codes Connexin 26. METHOD Participants were 36 subjects, ranging between 30 ...

Introduction There is only limited information from previous studies that suggest that auditory function may be influenced by hormones. Recent advances in the field have exposed the potential role of hormones in modulating the auditory system. Objective This study aims to investigate the relationship between menstrual cycle and outer hair cell function with audiological examination. Methods Thi...

A Labview-based Graphical User Interface (GUI) implementation of a technique of estimation of distortion product otoacoustic emissions (DPOAEs) is presented. The purpose of this work is to make the estimation method available to all users, independent of their level of expertise in signal processing. The basis of the work is a nonlinear adaptive algorithm developed by Dr. A. K. Ziarani. Three u...