The mevalonate pathway is essential for the production of many important molecules in lipid biosynthesis. Inhibition of this pathway is the mechanism of statin cholesterol-lowering drugs, as well as the target of drugs to treat osteoporosis, to combat parasites, and to inhibit tumor cell growth. Unlike the human mevalonate pathway, the bacterial pathway appears to be regulated by diphosphomeval...

The running time of existing algorithms in Frequent Pattern Mining (FPM) increases exponentially with increasing average data size. The existing algorithms on high dimensional datasets create large number of frequent patterns of small and mid sizes which are ineffective for decision making and shows deficiency on mining process. To discover large patterns or Colossal Patterns Doubleton Pattern ...

Burkholderia cenocepacia infects patients with cystic fibrosis. We have previously shown that B. cenocepacia can survive in macrophages within membrane vacuoles [B. cenocepacia-containing vacuoles (BcCVs)] that preclude fusion with the lysosome. The bacterial factors involved in B. cenocepacia intracellular survival are not fully elucidated. We report here that deletion of BCAM0628, encoding a ...

Erosion caused by sand transportation in flow changing devices is a serious concern in the hydrocarbon and mineral processing industry, which entail to failure and malfunction of flow devices. In this study, computational fluid dynamics (CFD) with discrete phase models (DPM) were employed for analysis of carbon steel long radius 90-Degree elbow erosion due to the sand concentration of 2, 5 and ...

OBJECTIVE The purposes of this study were to determine the following: 1) the exposure levels of municipal household waste (MHW) workers to diesel particulate matter (DPM) using elemental carbon (EC), organic carbon (OC), total carbon (TC), black carbon (BC), and fine particulate matter (PM 2.5) as indicators; 2) the correlations among the indicators; 3) the optimal indicator for DPM; and 4) fac...

In a previous study, the efficacy of commercial and prototype impactors for sampling diesel particulate matter (DPM) in coal mines was investigated. Laboratory and field samples were collected on quartz-fiber filters and analyzed for organic and elemental carbon. Coal dust contributed a minimal amount of elemental carbon when commercial cascade impactors and prototype impactors, designed by the...

The erosion of the fixed guide vane a hydraulic turbine by sandy water is influenced not only flow velocity and mud concentration but also direction speed over surface. This study aims to investigate erosive effect sediment-laden on specific type turbine’s vane, validate efficacy discrete phase model (DPM) in simulating wear identify critical areas its To achieve these objectives, DPM are emplo...

Abstract The hydraulic transients are obvious during the operation and adjustment of large-scale district heating (DH) network. Hydraulic transient modeling simulation methods can provide basis for efficient DH In this paper, two models, distributed parameter model (DPM) lumped (LPM), were established Efficient numerical algorithms presented models. proposed DPM LPM both applied to a network si...