With their potent regenerative and protective capacities, stem cell-derived conditioned media emerged as an effective alternative to cell therapy, have a prospect be manufactured pharmaceutical products for tissue regeneration applications. Our study investigates the neuroregenerative potential of human dental pulp cells (DPCs) medium (CM) defines optimization strategy DPC-CM enhanced neuronal ...

BACKGROUND Clinical applicability of newly discovered reagents for molecular imaging is hampered by the lack of translational models. As the dog prostate cancer (DPC-1) model recapitulates in dogs the natural history of prostate cancer in man, we tested the feasibility of single-photon emission computed tomography (SPECT)/CT imaging in this model using an anti-prostate-specific membrane antigen...

BACKGROUND The Israel Mental Health Act of 1991 stipulates a process for involuntary psychiatric hospitalization (IPH). A patient thus hospitalized may be discharged by either the treating psychiatrist (TP) or the district psychiatric committee (DPC). The decision rendered by the DPC is often at odds with the recommendation of the TP. Although much has been written about the ethical issues of r...

(S)-5, 6-Difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3, 4-dihydro- 2-(1H)-quinazolinone (DPC 963), a specific non-nucleoside inhibitor of human immunodeficiency virus-1 reverse transcriptase, is primarily metabolized in humans to the glucuronide conjugate of 8-OH DPC 963 (M8). Electrospray ionization-liquid chromatography/mass spectrometry analyses of urine from subjects dosed with DPC 963 ...

i ntroduction: the aim of this study was to evaluate the clinical and histological status of the pulp in sound human premolars after direct pulp capping (dpc) with four different dpc methods/materials. methods and materials: this study was conducted on eight volunteers who had to extract four first premolars due to orthodontic treatment. subsequent to tooth isolation, standardized class i occlu...

We prove that in a locally finite variety that has definable principal congruences (DPC), solvable congruences are nilpotent, and strongly solvable congruences are strongly abelian. As a corollary of the arguments we obtain that in a congruence modular variety with DPC, every solvable algebra can be decomposed as a direct product of nilpotent algebras of prime power size.

Di(2-pyridyl)ketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) and di(2-pyridyl)ketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) are novel, highly potent and selective anti-tumor and anti-metastatic drugs. Despite their structural similarity, these agents differ in their efficacy and toxicity in-vivo. Considering this, a comparison of their pharmacokinetic and pharmaco/toxico-dynamic prope...

Establishing the journal, Dermatology Practical & Conceptual (DPC), has been a tremendous challenge for us. Previously named Dermatopathology Practical & Conceptual by Bernie Ackerman, who was the visionary founder, DPC became more and more relevant under the editorship of Drs. Kittler, Zalaudek, Marghoob and Marchetti. When the journal became the official organ of the International Dermoscopy ...

Precision oncology entails making treatment decisions based on a tumor's molecular characteristics. For prostate cancer, identifying clinically relevant molecular subgroups is challenging, as molecular profiling is not routine outside of academic centers. Since histologic variants of other cancers correlates with specific genomic alterations, we sought to determine if ductal adenocarcinoma of t...

The intracellular distribution of a drug can cause significant variability in both activity and selectivity. Herein, we investigate the mechanism by which the anti-cancer agents, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) and the clinically trialed, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), re-instate the efficacy of doxorubicin (DOX), in drug-resista...