Prominin-1/CD133 (Prom1) is expressed by fibroblasts in the dermal papilla (DP) of the hair follicle (HF). By examining endogenous Prom1 expression and expression of LacZ in the skin of Prom1CreERLacZ (Prom1C-L) mice, in which a CreERT2-IRES-nuclear LacZ cassette is knocked into the first ATG codon of Prom1, we confirmed that Prom1 is expressed in the DP of all developing HFs and also by postna...

The high density of animal production in southeastern Coastal Plain watersheds has caused some soils to contain excess amounts of plant–available soil phosphorus (P). Runoff, erosion, and leaching can transport P to surface water systems and out of these watersheds. High P concentrations in downstream aquatic ecosystems can increase the risk of eutrophication. Our objectives were to determine s...

Clinical studies have demonstrated that HLA-DP-specific antibodies can be detrimental to a transplanted kidney. The number of patients affected is proportional to the frequency of DP antibodies. We determined the frequency of HLA-DP-specific antibodies en toto and in the absence of cross-reactive DR antibodies. Of 650 waitlisted renal patients, 271 (42%) were reactive with HLA-DP antigens in so...

Dynamic programming (DP) has long been used to solve optimisation problems. Though sometimes suffering from the curse of dimensionality, DP has a dowry of integrality. Integer programming (IP) often suffers interminable branch and bound, but brings the gift of flexibility. DP tends to be hard to program, but IP allows us to easily write models that are hard to solve. Until recently, DP and IP h...

BACKGROUND As the literature on long-term effects of childbirth on risk of morbidity or permanent work incapacity (DP) is limited, we aimed to study associations of childbirth with hospitalization and DP, adjusting for familial factors. METHODS This cohort study included female twins, i.e. women with twin sister, born 1959-1990 in Sweden (n = 5 118). At least one in the twin pair had their fi...

BACKGROUND The official statistics of persons with mental disorders who are granted disability pension (DP) in Russia and Norway indicate large differences between the countries. METHODS This qualitative explorative hypothesis-generating study is based on text analysis of the laws, regulations and guidelines, and qualitative interviews of informants representing all the organisational element...

The role of the Southern Ocean in global climate is examined using three simulations with a coupled model employing geometries different only at the location of Drake Passage (DP). The results of three main experiments are examined: 1) a simulation with DP closed, 2) an experiment with DP at a shallow (690 m) depth, and 3) a realistic DP experiment. The climate with DP closed is characterized b...

BACKGROUND The objective of this study was to investigate whether a distal protection (DP) device can preserve the index of microcirculatory resistance (IMR) after primary percutaneous coronary intervention (PCI) in patients with anterior ST-segment elevation myocardial infarction (STEMI). METHODS AND RESULTS The study group of 36 consecutive patients with anterior STEMI were randomized into ...

BACKGROUND Little is known about the factors influencing the future situation of individuals on sickness absence (SA) or disability pension (DP). The aim was to investigate whether being sickness absent is associated with future DP and premature death, and whether such associations can be explained by familial factors. METHODS A sample of 45 734 Swedish twins was followed for 13 years. Cox pr...