Recent studies have shown an increase in the frequency of traumatic brain injuries related to blast exposure. However, the mechanisms that cause blast neurotrauma are unknown. Blast neurotrauma research using computational models has been one method to elucidate that response of the brain in blast, and to identify possible mechanical correlates of injury. However, model validation against exper...

Antibiotic resistance in medically relevant bacterial pathogens, coupled with a paucity of novel antimicrobial discoveries, represents a pressing global crisis. Traditional drug discovery is an inefficient and costly process; however, systematic screening of Food and Drug Administration (FDA)-approved therapeutics for other indications in humans offers a rapid alternative approach. In this stud...

OBJECTIVE To compare two dosing regimens for caffeine citrate in the periextubation period for neonates born at less than 30 weeks gestation in terms of successful extubation and adverse effects. DESIGN A multicentre, randomised, double blind, clinical trial. SETTING Four tertiary neonatal units within Australia. PATIENTS Infants born less than 30 weeks gestation ventilated for more than ...

BACKGROUND On the basis of a retrospective survey by this unit it was suggested that patients with acute ventilatory failure should be given sufficient controlled oxygen treatment to raise the arterial oxygen tension (PaO2) to above 6.6 kPa, with the addition of a respiratory stimulant if the hydrogen ion concentration ([H+]) rose above 55 nmol/l and assisted ventilation if the patient remained...

The human body is critically dependent on the ventilatory control system for adequate uptake of oxygen and removal of carbon dioxide (CO2). Potent opioid analgesics, through their actions on μ-opioid receptor (MOR) expressed on respiratory neurons in the brainstem, depress ventilation. Opioid-induced respiratory depression (OIRD) is potentially life threatening and the cause of substantial morb...

Selec tiVe Respiratory Stimulating Ac t ion of Doxapram Conipared to Pentylenetet razol. KE N N ET H HIRSCH AND S. C. WANG 1 Behavioral Activities and Cardiovascular Function : Effects of Hexamethonium on Cardiovascular Changes during Strong Sustained Static Work in Rhesus Monkeys. P. B. 1)Ews AND J. A. HERD 12 Modification of the Effects of Chlorpromazine on Behavior in the Chimpanzee. LARRY D...

Selec tiVe Respiratory Stimulating Ac t ion of Doxapram Conipared to Pentylenetet razol. KE N N ET H HIRSCH AND S. C. WANG 1 Behavioral Activities and Cardiovascular Function : Effects of Hexamethonium on Cardiovascular Changes during Strong Sustained Static Work in Rhesus Monkeys. P. B. 1)Ews AND J. A. HERD 12 Modification of the Effects of Chlorpromazine on Behavior in the Chimpanzee. LARRY D...

Increasing knowledge about disorders of the central nervous system in humans – better understanding pathophysiology, developing more effective treatments, or both is long-term goal a substantial portion our animal studies. For that reason, translatability experimental findings utmost importance. This translation, course, can go ways; either emulating human situation nonhuman subjects, using res...

Acute angle closure glaucoma is a medical emergency which can result in blindness. As it is very painful patients are usually referred rapidly to an ophthalmologist. If it occurs following general anaesthesia however, the diagnosis may not be considered and symptoms such as pain and vomiting wrongly attributed. Delayed diagnosis puts the patient at risk both from the ocular complications of acu...