Microencapsulation of peptides and proteins has recently become a relevant alternative to develop novel drugdelivery systems. Among techniques designed to microencapsulate substances of different nature, the interfacial polymerization, spray-drying and solvent evaporation techniques are those most widely studied for encapsulation of biomolecules. The solvent double emulsion-evaporation procedur...

Double emulsion solvent evaporation technique is one of the most attractive methods used to prepare micro and nanoparticles in pharmaceutical areas of interest, but because of the effects of many formulation factors on the size and release behavior of the fabricated particles, optimization of the formulation factors is needed. In this study various parameters including technical and composition...

Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible member of the aliphatic polyester family of biodegradable polymers. PLGA has long been a popular choice for drug delivery applications, particularly since it is already FDA-approved for use in humans in the form of resorbable sutures. Hydrophobic and hydrophilic drugs are encapsulated in PLGA particles via single- or double-emulsion. Brief...

Microspheres are multiparticulate drug delivery systems which are prepared to obtain prolonged or controlled drug delivery to improve bioavailability, stability and to target the drug to specific site at a predetermined rate. They are made from polymeric waxy or other protective materials such as natural, semi synthetic and synthetic polymers. Microspheres are characteristically free flowing po...

Our previous study revealed that the peptide Val-Leu-Pro-Val-Pro-Arg (VLPVPR), which was prepared using deoxyribonucleic acid recombinant technology, effectively decreased the blood pressure of spontaneous hypertensive rats; however, the effect only lasts 6 hours, likely due to its low absorption in the gastrointestinal tract. To overcome this problem, the purpose of this study was to character...

The purpose of this study was to produce oil in water Nano-emulsion by ultrasonication, and investigate the influence of Inulin and β-cyclodextrin on the prosperities of Nano-emulsion and morphology of spray dried microcapsules. The results showed that emulsion droplet size in samples containing β-cyclodextrin (8.28±0.11 nm) was less than Inulin samples (97.12±4.2 nm). Considering SEM photos, β...

The purpose of this study was to produce oil in water Nano-emulsion by ultrasonication, and investigate the influence of Inulin and β-cyclodextrin on the prosperities of Nano-emulsion and morphology of spray dried microcapsules. The results showed that emulsion droplet size in samples containing β-cyclodextrin (8.28±0.11 nm) was less than Inulin samples (97.12±4.2 nm). Considering SEM photos, β...

Giant Unilamellar Vesicles (GUV) have the potential to play a dominating role in future scientific efforts to understand and model biological systems through the creation of artificial cells. GUV:s span a wide range of possible applications that include their use as biosensors, cell encapsulation agents and biomicroreactors. In order to allow GUV:s to reach their full potential, efficient, reli...

Studies of the therapeutic efficacy of coenzyme Q10 (CoQ10) have been confounded by the variable bioavailability of numerous CoQ10 preparations. The aims of the present study were to determine the early serum levels attained by two different preparations of CoQ10, a soybean oil-based preparation and a complex micelle emulsion and to assess whether these preparations of oral CoQ10 influence plas...

The absorption spectrum of indocyanine green (ICG), a nontoxic dye used for medical diagnostics, depends upon its concentration as well as the nature of its environment, i.e., the solvent medium into which it is dissolved. In blood, ICG binds with plasma proteins, thus causing changes in its photoacoustic spectrum. We successfully encapsulated ICG in an ultrasound-triggerable perfluorocarbon do...