نتایج جستجو برای: dopaminergic neurons da

تعداد نتایج: 523915  

Journal: :Antioxidants & redox signaling 2005
April A Dukes Kimberly M Korwek Teresa G Hastings

Deficiencies in Complex I have been observed in Parkinson's disease (PD) patients. Systemic exposure to rotenone, a Complex I inhibitor, has been shown to lead to selective dopaminergic cell death in vivo and toxicity in many in vitro models, including dopaminergic cell cultures. However, it remains unclear why rotenone seems to affect dopaminergic cells more adversely. Therefore, the role of d...

Journal: :Journal of molecular biology 2011
Carolina A Braga Cristian Follmer Fernando L Palhano Elias Khattar Mônica S Freitas Luciana Romão Saviana Di Giovanni Hilal A Lashuel Jerson L Silva Debora Foguel

Parkinson's disease (PD) is a movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra and the formation of intraneuronal inclusions called Lewy bodies, which are composed mainly of α-synuclein (α-syn). Selegiline (Sel) is a noncompetitive monoamino oxidase B inhibitor that has neuroprotective effects and has been administered to PD patients as monotherapy or ...

2012
Dianshuai Gao Yi Liu Shen Sun Li Li Ye Xiong

Parkinson's disease (PD) is a degenerative disease of the central nervous system (CNS) predominantly occurring in older adults, and is particularly common after the age of 60. The primary pathologic characteristics of PD are neuronal degeneration and cell death of dopaminergic (DA-ergic) neurons, leading to a decrease in the dopamine (DA) level in the striatum. Originally extracted and purified...

Journal: :Journal of neurochemistry 2001
R Martín-Ruiz L Ugedo M A Honrubia G Mengod F Artigas

We studied the control of dorsal raphe (DR) serotonergic neurons by dopaminergic transmission in rat brain using microdialysis and single unit extracellular recordings. Apomorphine (0.5-3.0 mg/kg s.c.) and quinpirole (0.5 mg/kg s.c.) increased serotonin (5-HT) output in the DR and (only apomorphine) in striatum. These effects were antagonized by 0.3 mg/kg s.c. SCH 23390 (in DR and striatum) and...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Chee Yeun Chung James B Koprich Penelope J Hallett Ole Isacson

In Parkinson's disease (PD), dopaminergic (DA) neurons in the substantia nigra (SN, A9) are particularly vulnerable, compared to adjacent DA neurons within the ventral tegmental area (VTA, A10). Here, we show that in rat and human, one RAB3 isoform, RAB3B, has higher expression levels in A10 compared to A9 neurons. RAB3 is a monomeric GTPase protein that is highly enriched in synaptic vesicles ...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Sarah B Appel Leon Wise John McDaid Susumu Koyama Maureen A McElvain Mark S Brodie

The dopaminergic neurons of the ventral tegmental area (DA VTA neurons) have been implicated in the reinforcing properties of drugs of abuse, including ethanol (ethyl alcohol). Ethanol increases the spontaneous firing frequency of DA VTA neurons in vitro, in both brain slices and acutely dissociated neurons, and also in vivo. In many systems, longer n-alkyl alcohols have a more potent effect th...

2009
Jerrad Thomas Faiza Ferdousy Janis M. O’Donnell

The neurotransmitter dopamine and its role in neurological diseases The biogenic catecholamine dopamine (DA) functions mainly as a neurohormone and neurotransmitter. It also functions as an intermediary step in the biosynthesis of norepinephrine and epinephrine, structurally similar catecholamines that serve as cell regulators and neurotransmitters in mammals. The neurotransmitter function of D...

2018
Juliana Cackovic Susana Gutierrez-Luke Gerald B. Call Amber Juba Stephanie O’Brien Charles H. Jun Lori M. Buhlman

Selective degeneration of substantia nigra dopaminergic (DA) neurons is a hallmark pathology of familial Parkinson's disease (PD). While the mechanism of degeneration is elusive, abnormalities in mitochondrial function and turnover are strongly implicated. An Autosomal Recessive-Juvenile Parkinsonism (AR-JP) Drosophila melanogaster model exhibits DA neurodegeneration as well as aberrant mitocho...

2014
Lars Brichta Paul Greengard

Numerous disorders of the central nervous system (CNS) are attributed to the selective death of distinct neuronal cell populations. Interestingly, in many of these conditions, a specific subset of neurons is extremely prone to degeneration while other, very similar neurons are less affected or even spared for many years. In Parkinson's disease (PD), the motor manifestations are primarily linked...

2004
Floriana Volpicelli Claudia Consales Massimiliano Caiazzo Luca Colucci-D'Amato Carla Perrone-Capano Umberto di Porzio

We analyzed the molecular mechanisms involved in the acquisition and maturation of dopaminergic (DA) neurons generated in vitro from rat ventral mesencephalon (MES) cells in the presence of mitogens or specific signaling molecules. The addition of basic fibroblast growth factor (bFGF) to MES cells in serum-free medium stimulates the proliferation of neuroblasts but delays DA differentiation. Re...

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