Parkinson's disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear medicine radiotracers have been developed to evaluate PD diagnoses and disease evolution in vivo in PD patients. Positron emission tomography (PET) and single photon computerized emission tomography (SPECT) radiotracers for the dopamine trans...

In this study we present the use of elastic macroporous cryogels for differentiation and transplantation mature neurons. We develop a coating suitable long-term neuronal culture, including stem cell differentiation, by covalent immobilization neural adhesion proteins. context therapy Parkinson's disease, show compatibility with established dopaminergic both immortalized mesencephalic progenitor...

This study analyzes the electrophysiological cause and behavioral consequence of dopaminergic cell loss in a knock-in mouse strain bearing hypersensitive nicotinic 4 receptor subunits (“L9’S mice”). Adult brains of L9’S mice show moderate loss of substantia nigra dopaminergic neurons and of striatal dopaminergic innervation. Amphetamine-stimulated locomotion is impaired, reflecting a reduction ...

* Texto resultante de entrevista concedida a Rosa Maria Godoy Serpa da Fonseca e Emiko Yoshikawa Egry, Professoras Titulares do Departamento de Enfermagem em Saúde Coletiva da Escola de Enfermagem da Universidade de São Paulo e consultoras do Sistema de Certificação de Competências do Projeto de Profissionalização dos Trabalhadores da Área de Enfermagem – PROFAE Ministério da Saúde. 1 Enfermeir...

Motivation incorporates several psychological aspects that produce reward-related and learning behaviors. Although reward-related behavior is reported to be mediated by the dopaminergic reward pathway, the involvement of dopaminergic systems in motivated behavior has not been fully clarified. Several experimental methodologies for motivational behavior have been reported, but pharmacological ch...

Dopamine is an essential neuromodulator of the central nervous system whose activity is mediated through interaction with membrane receptors. Among these, the D2 receptor plays a pivotal role in regulating postsynaptic functions as well as dopamine synthesis and release from dopaminergic neurons. Parkinson's disease and parkinsonism are neurodegenerative diseases of dopaminergic neurons affecti...