Article history: Received 8 October 2012 Received in revised form 15 October 2014 Accepted 7 November 2014 Available online xxxx Communicated by D. Sannella

Trichothecene mycotoxins such as deoxynivalenol (DON) are known to modulate the immune function, but to this date only few studies have been conducted with farm animals, especially pigs, which are regarded as most susceptible to this mycotoxin. Mitogen-stimulated proliferation of porcine blood lympho­ cytes was measured using two different assays, the MTT cleav­ age (metabolic activity) and the...

Deoxynivalenol (DON) is one of several mycotoxins produced by certain Fusarium species that frequently infect corn, wheat, oats, barley, rice, and other grains in the field or during storage. It is a toxic byproduct of Fusarium head blight in grains and feeds. Potential human exposure to DON may occur from ingestion of products made from contaminated grains. It has been detected in buckwheat, p...

The trichothecene mycotoxin deoxynivalenol (DON) is a contaminant of crops worldwide and known to cause adverse health effects in exposed animals and humans. A small survey reported the presence of DON in maize samples in Bangladesh, but these data are insufficient to assess human exposure, and also, biomonitoring data are still scarce. The present study applied biomarker analysis to investigat...

Introduction: Plusieurs facteurs font obstacles au don de sang dans les pays en développement. La présente étude avait pour objectifs d'analyser les connaissances, attitudes et pratiques de la population de Kisangani relatives au don de sang et d'identifier les obstacles au don de sang afin de guider la planification des activités de promotion du don de sang. Méthodes: L' enquête a été réalisée...

The mycotoxin deoxynivalenol (DON) is an abundant contaminant of cereal based food and a severe issue for global food safety. We report the discovery of DON-3-sulfate as a novel human metabolite and potential new biomarker of DON exposure. The conjugate was detectable in 70% of urine samples obtained from pregnant women in Croatia. For the measurement of urinary metabolites, a highly sensitive ...

Deoxynivalenol (DON) is a widespread trichothecene mycotoxin that commonly contaminates cereal crops and has various toxic effects in animals and humans. DON primarily targets the gastrointestinal tract, the first barrier against ingested food contaminants. In this study, an isobaric tag for relative and absolute quantitation (iTRAQ)-based phosphoproteomic approach was employed to elucidate the...

Immunoaffinity columns (IACs) are a well-established tool in the determination of regulated mycotoxins in food and feed commodities. However, they also have the potential to become attractive pre-concentration and clean-up materials for the determination of masked (also called modified) mycotoxins, which have been recognised as important contributors to the toxicological hazard deriving from fun...

Background: Deoxynivalenol (DON) and zearalenone (ZEN) are common food contaminants produced by Fusarium sp. Mycotoxins are a potential health hazard because of their toxicological effects on both humans and farmed animals. Methods: We analyzed three groups of pigs: a control group (fed a standard diet), and the DON and ZEN groups, fed a diet containing 8 mg/kg DON and 0.8 mg/kg ZEN respectivel...