Temozolomide (TZM) is a DNA-methylating agent that has recently been introduced into various clinical trials for treatment of solid or hematologic neoplasias, including brain lymphomas. In the current study, we have investigated whether the antitumor activity of TZM could be selectively enhanced at the central nervous system (CNS) site by intracerebral injection of a poly(ADP-ribose) polymerase...

a group of critics believe that “stray dog” is among the stories of hedāyat which is written under the influence of sartre’s existentialism. this story, following an existentialist outlook, depicts human pain and helplessness. “pat”, the stray dog, is a symbol of nostalgia which ruins our life. this paper tries to trace out the representation of the existentialism and sartre’s interpretation of...

BACKGROUND Many people live with dogs but not all walk with them regularly. This study examines the demographic and behavioural factors that contribute towards owners reporting having a strong sense of encouragement and motivation to walk provided by their dogs, which we call 'the Lassie effect'. METHODS Data was collected from 629 dog owners participating in the RESIDE cross-sectional survey...

Abstract The ability to delay gratification is related success in school and other aspects of life. Genetic as well environmental factors such parenting style partly explain the development (DoG). However, it unclear whether parental personality impacts children’s DoG, how maternal paternal personalities contribute this relationship. present study investigates relationship between 45-month-old ...

a 7-year-old castrated male german shepherd dog was presented with a 10-day history of intermittent lethargy, weakness and episodic seizures. laboratory findings after admission revealed hypoglycaemia and hyperinsulinaemia. provisional diagnosis of insulinoma was made based on the presence of concurrent hypoglycaemia and elevated insulin level. in exploratory laparotomy a small nodular mass was...

the present study was carried out to determine whether helicobacter spp. infection in dogs could affect lesions caused by the non-steroidal anti-inflammatory drugs (nsaids), aspirin and celecoxib. thirty asymptomatic mixed-breed dogs were used for this study. gastric biopsies were taken via gastroscopy and evaluated by polymerase chain reaction (pcr) and rapid urease tests (rut). helicobacter s...

a one-month-old male terrier dog was referred in shock status with a history of anorexia, tachypnea, abdominal distention and progressive weight loss. auscultation of right side of the lungs found enhanced respiratory noises. the thorough auscultation of the opposite side of the chest revealed the presence of typical intestinal sounds. cardiac auscultation revealed muffled heart sounds and a di...

background: the aim was to study the gastro-intestinal helminths of stray dogs of garmsar, sem­nan province, central iran, and its impacts on human health and animal production. methods : during 2006, the alimentary tracts of 50 stray dogs at necropsy, selected from villages around garmsar, were removed, and examined for helminth infections. subsequently helminths were collected from the conten...