BACKGROUND We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with concomitant and adjuvant temozolomide or temozolomide alone. As DNA-methyltransferases (DNMTs) are the enzymes responsible for setting up and maintaining ...

BACKGROUND Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is a common dietary component that has histone deacetylase inhibition activity and exciting potential in cancer prevention. The mechanisms by which SFN imparts its chemopreventive properties are of considerable interest and little is known of its preventive potential for breast cancer. PRINCIPAL FINDINGS We foun...

Working memory (WM) is a memory system responsible for the temporary storage of information and its utilization in problem solving. The central executive is theorized as the controller of storage functions that support WM. Neurophysiological data suggest that electroencephalographic (EEG) theta and alpha oscillations in frontal and midline regions are involved in neural communication between th...

DNA methylation and demethylation are epigenetic mechanisms involved in memory formation. In honey bees DNA methyltransferase (Dnmt) function is necessary for long-term memory to be stimulus specific (i.e. to reduce generalization). So far, however, it remains elusive which genes are targeted and what the time-course of DNA methylation is during memory formation. Here, we analyse how DNA methyl...

This Article contains an error in the order of the Figures. Figures 3 and 4 were published as Figures 4 and 3 respectively. The correct Figures 3 and 4 appear below as Figs 1 and 2 respectively. The Figure legends are correct.

DNA methylation is an essential epigenetic mechanism influencing gene expression in all organisms. In metazoans, the pattern of changes during embryogenesis and adult life. Consequently, differentiated cells develop a stable unique that finely regulates mRNA transcription development determines tissue-specific expression. Currently, remains poorly investigated mollusks completely unexplored Myt...

Migraine is a common, disabling disorder characterized by attacks of 4 to 72 h severe headache and associated autonomic neurological symptoms. In the present study we analyzed expression DNMT1, DNMT3a, DNMT3b in patients with migraine compared healthy controls as well association between levels DNMTs LINE-1 methylation status MTHFR C677T variant. Materials Method: A total 48 individuals we...