we have previously shown that the proliferative response of t cells to antigenic or mitogenic stimulus decreased with age and that caloric resection (cr) attenuated the age-related decline in proliferation and il-2 expression. because activation-induced apoptosis is known to regulate cell proliferation and eliminate the high number of activated cells during an immune response, it was of interes...

Little information exists about boar sperm chromatin quality and fertility within a commercial setting. The objective of this report is to provide information about boar sperm chromatin integrity and its relationship to fertility. The sperm chromatin structure assay (SCSA) was used retrospectively to characterize sperm from 18 sexually mature boars having fertility information. Boar fertility w...

Hann, Wendel J.; Wisdom, Michael J.; Rowland, Mary M. 2003. Disturbance departure and fragmentation of natural systems in the interior Columbia basin. Res. Pap. PNW-RP-545. Portland, OR: U.S. Department of Agriculture, Forest Service, Pacific Northwest Research Station. 19 p. We integrated landscape data from science assessments of the interior Columbia basin (basin) into one variable that func...

BACKGROUND/AIMS A large proportion of men with normal sperm results as analyzed using conventional techniques have fragmented DNA in their spermatozoa. We performed a prospective study to examine the incidence of DNA fragmentation in sperm in cases of couples with previously unexplained infertility and treated with intrauterine insemination. We evaluated whether there was any predictive value o...

Received: 21 January, 2014 Accepted: 30 March, 2014 Published: 20 April, 2014 A study was conducted to investigate the effect Gonadotropins supplied to culture medium on human sperm parameters and sperm DNA structure during in vitro sperm activation. Thirty infertile patients were included. Semen sample was divided into 3 aliquots. One mL of SMART medium either alone (control group) or supplied...

Taxol (paclitaxel, PAC) is a diterpene with antitumor activity against a variety of human neoplasms. PAC cytotoxicity is thought to derive mainly from a stabilization of microtubules as a result of enhanced tubulin polymerization that leads to an accumulation of cells in G2/M phase of cell cycle. In this study, the cytotoxic effect occurred by PAC in tumor cells in vitro were examined. Mouse ma...

OBJECTIVE To measure sperm DNA integrity values before and after varicocelectomy in patients with elevated preoperative levels of sperm DNA fragmentation. DESIGN Retrospective. SETTING Private urology clinic. PATIENT(S) Eleven patients with grade 1, 2, or 3 varicocele. INTERVENTION(S) Varicocelectomy. MAIN OUTCOME MEASURE(S) Sperm DNA fragmentation values were assessed before and afte...

BACKGROUND Radiocontrast-induced nephropathy is a clinically important complication of invasive cardiological procedures. It has been associated with DNA fragmentation of renal tubular cells, which is a hallmark feature of programmed cell death (apoptosis). We investigated the mechanism of this DNA fragmentation in an in vitro model of radiocontrast cytotoxicity on renal epithelial cells. MET...