Significance In transcription factors’ search for target genes, one-dimensional diffusion of the protein along DNA is essential. Experimentally, it remains challenging to resolve individual diffusional steps on DNA. Here, we report mainly all-atom equilibrium simulations a WRKY domain in association with and We demonstrate complete stepping cycle one base pair within microseconds, stochastic mo...

Nickel phthalocyanine complex containing 4-(3,4-dicyanophenoxy)-3-methoxybenzoic acid group was synthesized and specified by way of FT-IR, NMR, UV/Vis procedures. The binding PcNi to CT-DNA examined via electronic absorption titration, emission melting temperature, viscosity measurement, agarose gel electrophoresis technics, respectively. DNA interaction activity against studied UV/Vi titration...

The aggregation behavior of anionic Cobalt(II) 4,4′,4ʺ,4‴-tetrasulfonated phthalocyanine, [Co(TSPc)4-] was studied at its various concentrations and different ionic strengths using optical absorption and resonance light scattering (RLS) spectroscopies in 5 mM phosphate buffer, pH 7.0 at 25 °C. The results show no aggregation behavior at concentration range of 5.1 × 10-6-7....

Nature uses non-covalent interactions to achieve structural dynamic reconfiguration of biopolymers. Taking advantage the programmability DNA/DNA we report here rational design orthogonal DNA-based addressable tiles that self-assemble into polymer-like structures can be reconfigured by external inputs. The different share same sticky ends responsible for self-assembly but are rationally designed...

One of the most important mechanism by which bioflavonoids can exert their effects in cancer treatment, is through interaction with bio-macromolecules such as DNA. Recent literature emphasizes role Bavachinin (BVC) an emerging anticancer agent. However, there are no reports on its ability to interact The present study investigated DNA binding properties BVC many spectroscopic and computational ...

Abstract Immune cell development is a tightly controlled process that enables homeostatic level of innate and adaptive immune cells the myeloid lymphoid lineages, respectively. Imbalance in can lead to diseases due defects or over-activation. such as immunodeficiency, allergies autoimmunity. Ikaros transcription factor known be critically important for development, with recurrent mutations diff...