A differentially methylated region (DMR) and endoderm-specific enhancers, located upstream and downstream of the mouse H19 gene, respectively, are known to be essential for the reciprocal imprinting of Igf2 and H19. To explain the same imprinting patterns in non-endodermal tissues, additional enhancers have been hypothesized. We determined and compared the sequences of human and mouse H19 over ...

Runt-related transcription factor 2 (Runx2) is essential for osteogenesis. This study aimes at identification of the genomic region differentially methylated in DNA for regulation of Runx2 expression. In the proximal promoter of mouse Runx2, DNA methylation was frequent at the region further than 3 kb relative to the transcription start site, in contrast to lower methylation status of the close...

In this Letter we present a summary of the spatial properties of the cosmic microwave background radiation based on the full 4 yr of COBE Differential Microwave Radiometer (DMR) observations, with additional details in a set of companion Letters. The anisotropy is consistent with a scale-invariant power-law model and Gaussian statistics. With full use of the multifrequency 4 yr DMR data, includ...

Objective The aim of this study was to explore the views of community pharmacists participating in the pilot of a secure online platform in Wales, the Choose Pharmacy application (CPA), with particular interest in the electronic Discharge Advice Letters (e-DALs) and online Discharge Medicines Review (DMR) form. Materials and methods A qualitative approach with semi-structured interviews was a...

Epigenetic regulation, such as DNA methylation plays an important role in the control of imprinting. Lsh, a member of the SNF2 family of chromatin remodeling proteins, controls DNA methylation in mice. To investigate whether Lsh affects imprinting, we examined CpG methylation and allelic expression of individual genes in Lsh-deficient embryos. We report here that loss of Lsh specifically alters...

Recommendation services become an essential and hot research topic for researchers nowadays. Social data such as Reviews play important role in the recommendation of products. Improvement was achieved by deep learning approaches capturing user product information from a short text. However, previously used do not fairly efficiently incorporate users’ preferences characteristics. The proposed no...

We cross-correlate the COBE 6 DMR 2-year sky maps with spatial templates from long-wavelength radio surveys and the far-infrared COBE DIRBE maps. We place an upper limit on the spectral index of synchrotron radiation β synch < −2.9 between 408 MHz and 31.5 GHz. We obtain a statistically significant cross-correlation with the DIRBE maps whose dependence on the DMR frequencies indicates a superpo...

Parallel and distributed computing on clusters of workstations is becoming very popular as i t provides a cost effective way for high performance computing. In these systems, the bandwidth of the communication subsystem (Using Ethernet technology) is about an order of magnitude smaller compared to the bandwidth of the storage subsystem. Hence, storing a state in a checkpoint is much more eficie...

Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children under the age of 15. In addition to genetic aberrations, epigenetic modifications such as DNA methylation are altered in cancer and impact gene expression. To identify epigenetic alterations in ALL, genome-wide methylation profiles were generated using the methylated CpG island recovery assay followed by next-gen...

Purpose: It is thought that arrhythmias are responsible for sudden deaths in patients with mitral valve prolapse (MVP). QT intervals may predict malignant arrhythmia potential in these patients. The aim of the present study is to assess QT variables in patients with MVP. Methods : We studied 46 patients with non-rheumatic, uncomplicated and isolated MVP and 25 healthy control subjects. All indi...