نتایج جستجو برای: dlbcl
تعداد نتایج: 2906 فیلتر نتایج به سال:
Abnormal expression of the chemokine receptor CXCR4 plays an essential role in tumor cell dissemination and disease progression. However, the significance of CXCR4 overexpression in de novo diffuse large B cell lymphoma (DLBCL) is unknown. In 743 patients with de novo diffuse large B cell lymphoma (DLBCL) who received standard Rituximab-CHOP immunochemotherapy, we assessed the expression of CXC...
The epigenetic dysregulation of tumor suppressor genes is an important driver of human carcinogenesis. We have combined genome-wide DNA methylation analyses and gene expression profiling after pharmacological DNA demethylation with functional screening to identify novel tumor suppressors in diffuse large B cell lymphoma (DLBCL). We find that a CpG island in the promoter of the dual-specificity ...
This study aims to investigate the role and mechanism of miR-34a in diffuse large B-cell lymphoma (DLBCL). Totally 30 DLBCL patients and 30 reactive lymph node hyperplasia patients were selected as DLBCL group and control group respectively. Lymph node tissues were collected. The miR-34a inhibitors or mimics were transfected into OCI-LY10 cells. RT-qPCR was performed to detect levels of miR-34a...
To elucidate the mechanisms underlying chromosomal translocations in diffuse large B cell lymphoma (DLBCL), we investigated the nature and extent of immunoglobulin class switch recombination (CSR) in these tumors. We used Southern blotting to detect legitimate and illegitimate CSR events in tumor samples of the activated B cell-like (ABC), germinal center B cell-like (GCB), and primary mediasti...
UNLABELLED Diffuse large B-cell lymphoma (DLBCL) represent the most frequently non-Hodgkin's lymphoma (NHL) (over 30%), especially in developing countries. Many associations of NHL with another neoplasia were described following chemotherapy or radiotherapy regimens. The coexistence of DLBCL with myeloproliferative neoplasms (MPNs) JAK2V617F positive at the onset was very rare reported in the l...
Diffuse large B-cell lymphoma (DLBCL) is one of the most common and aggressive types of B-cell lymphoma. Deregulation of proto-oncogene expression after a translocation, most notably to the immunoglobulin heavy-chain locus (IGH), is one of the hallmarks of DLBCL. Using whole-genome sequencing analysis, we have identified the PD-L1/PD-L2 locus as a recurrent translocation partner for IGH in DLBC...
The prognosis of CD20-positive (CD20+) diffuse large B-cell lymphoma (DLBCL) with central nervous system (CNS) recurrence is still poor. A standard treatment for CD20+ DLBCL with CNS recurrence in elderly patients has not been established mainly due to adverse effects. We previously reported the efficacy and safety of MIND-E (ranimustine, ifosfamide, procarbazine, dexamethasone, and etoposide) ...
The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL o...
Diffuse large B-cell lymphoma (DLBCL) is the term applied to a constellation of different disorders with specific clinicopathological features [1]. All DLBCL cases are distinguished by a diffuse pattern of infiltration and a cytological composition by large Bcells. Despite these common features, DLBCL cases may have strikingly different clinical presentations, immunophenotype, molecular pathoge...
Introduction Diffuse large B-cell lymphoma (DLBCL), the most common adult non-Hodgkin lymphoma, is well recognized as a heterogeneous disease. Although clinical indicators such as the International Prognostic Index (IPI) are used to define prognostic subgroups of DLBCL, less than half of the patients with this disease are cured by currently available therapy. At present, a consensus approach fo...
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