INTRODUCTION Anemia and hyperhomocysteinemia are risk factor of mortality of patients on dialysis. This study was conducted to assess the relationship of hemoglobin and homocysteine levels and mortality of patients on hemodialysis. MATERIALS AND METHODS Fifty patients on hemodialysis and 20 healthy individuals were enrolled in the study. Blood samples were drawn for measurement of hematologic...

UNLABELLED Essentials Evidence suggests a comorbidity between hyperhomocysteinemia (HHC) and Alzheimer's disease (AD). Homocysteine (HC) could affect the β-amyloid (Aβ)-fibrinogen interaction in AD pathology. AD patients with concomitant HHC have increased fibrin and Aβ deposits in their brains. HC contributes to AD pathology via the Aβ-fibrinogen interaction. SUMMARY Background Accumulating ...

From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany St., W-507, Boston, MA 02118, where reprint requests should be addressed to Dr. Loscalzo. ©1998, Massachusetts Medical Society. N 1969, McCully made the clinical observation linking elevated plasma homocyst(e)ine concentrations with vascular disease. 1 He reported autops...

Background and aim: Homocysteine adropin effects on endothelial function are antagonistic. The current study aimed to evaluate the association between serum levels of homocysteine severity coronary artery disease (CAD) . Patients methods: This cross-sectional included 86 patients submitted angiography with ≥ 50% stenosis in one or more arteries. Serum Adropin were estimated. anatomical synergy ...

Homocystinuria is an inherited disease of homocysteine metabolism most commonly caused by deficiency of the pyridoxal phosphate-dependent enzyme, cystathionine synthase. The disease is manifested in many cases by accelerated growth in childhood, dislocated ocular lenses, skeletal abnormalities, retarded mental development, and propensity to thrombosis with increased mortality from vascular dise...

BACKGROUND Hyperhomocysteinemia is a putative risk factor for cardiovascular disease, which also impairs endothelium-dependent vasodilatation. A number of other risk factors for cardiovascular disease may exert their adverse vascular effects in part by elevating plasma levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase. Accordingly, we determined if h...