A 52-year-old man was found dead in his bed. He had financial and psychosocial problems like separation from his wife and children or unemployment due to alcoholism. Under treatment of disulfiram he was presently abstinent from alcohol. As he had suffered from epileptic seizures and dizziness, he received valproic acid and the vasodilator naftidrofuryl, respectively. Autopsy showed no morpholog...

Disulfiram was the first pharmacotherapy approved to treat alcohol use disorder in the 1950s. Disulfiram alters ethanol pharmacokinetics and causes uncomfortable reactions (e.g. headache, tachycardia, nausea, flushing and hypotension) when alcohol is consumed. Subsequently, a better understanding of the neurobiological pathways involved in alcohol use disorder led to the development of other me...

Fundamental problems in the current treatment of patients with metastatic colorectal cancer (mCRC) are a lack new effective drugs and high percentage mCRC receiving chemotherapy that do not benefit from due to inherited or acquired drug resistance. We present repurposing strategy by introducing disulfiram irinotecan-resistant disease. Bartek et al. (Nature 2017) describe detail molecular mechan...

COVID-19 is a disease caused by SARS-CoV-2, virus that represents serious threat to global health. The objective of the article deepen into structure structural and non-structural proteins SARS-CoV-2 their role during infection its target cells; also propose molecules from in silico studies inhibit viral cycle for potential pharmacological treatments. genome has ORFs encode sixteen (Nsp1-16), f...