Cycloaddition is a fundamental transformation, featuring the assembly of complex cyclic molecules with multiple stereocenters. We report here silver-catalyzed [3+2]-cycloaddition 2,3-disubstituted cyclobutenones an array azomethine ylide...

An efficient synthesis of 3-substituted or 2,3-disubstituted 4(3H)-quinazolinones from benzoxazin-4-ones and primary amines under microwave irradiation in unsealed vessels is described.

The 2-mono and 2,6-disubstituted methyl-1,4-dihydropyridines were synthesized by reaction of morpholine, thiophenol, 8-hydroxyquinoline, 2-naphthol and 2-mercopto-1-methyl imidazole with the 2-mono bromo and 2,6-dibromo-1,4-dihidropyridines.

Reactions of  N-isocyaniminotriphenylphosphorane with α- chloroketones in the presence ofaromatic carboxylic acids proceed smoothly at room temperature and in neutral conditions toafford new disubstituted 1,3,4-oxadiazole derivatives in high yields.

Dihydroxylation of (R,S) or (S,S)-2,6-disubstituted dehydropiperidines enantioselectively obtained from stannylated precursors allows a versatile preparation 2-deoxyiminosugar C-glycosides which have been evaluated as glycosidases inhibitors.

Herein, we report the first palladium/MPAA catalyzed enantioselective C-H activation/[4+1] annulation of diarylmethyltriflamide and olefins to construct chiral cis-1,3-disubstituted isoindoline derivatives. The use readily accessible mono N-protected amino acid...