Shippers and motor carriers are impacted by and react differently to travel time variability due to their positions within the supply chain and end goals. Through interviews and focus groups these differences have been further examined. Shippers, defined here as entities that send or receive goods, but do not provide the transportation themselves, are most often concerned with longer-term disru...

Parkinson’s disease (PD) is a neurodegenerative condition characterized by disruptions in both fine movement control and motor learning. Pathologically, these disruptions are attributed to the loss of dopamine neurons in the midbrain (a region of the brainstem). While it is known that changes in synaptic plasticity are important for learning new motor skills and maintaining memory throughout li...

This paper develops and analyzes a simplified model of the dynamics of delay propagation in air traffic networks. The proposed model considers the redistribution of delays by accounting for aircraft flows between airports, the persistence of delays at an airport, the mitigation of delays due to slacks or buffers in flight schedules, and inputs such as sudden impulsive disruptions or sustained i...

We consider the single machine scheduling problem with dynamic job arrival and total weighted tardiness and makespan as objective functions. The machine is subject to disruptions related to late raw material arrival and machine breakdowns. We propose a proactive-reactive approach to deal with possible perturbations. In the proactive phase, instead of providing only one schedule to the decision ...

A crew scheduling algorithms widely used in practice assume no disruptions. Because disruptions often occur, the actual cost of the resulting crew schedules is often greater. We consider algorithms for finding crew schedules that perform well in practice. The deterministic crew scheduling model is an approximation of crew scheduling under uncertainty with the assumption that all pairings will o...

A hot research topic in Genome Science is to analyze the interactions between genes by systematic gene disruptions and gene overexpressions. This paper analyzes the problem of identifying a gene regulatory network from data obtained by multiple gene disruptions and overexpressions in regard to the number of experiments and the complexity of experiments. An experiment consists of a parallel gene...

DNA bending and torsional deformations that often occur during its functioning inside the cell can cause local disruptions of the regular helical structure. The disruptions created by negative torsional stress have been studied in detail, but those caused by bending stress have only been analyzed theoretically. By probing the structure of very small DNA circles, we determined that bending stres...

In this paper, we develop a supply chain/logistics network model for critical needs in the case of disruptions. The objective is to minimize the total network costs, which are generalized costs that may include the monetary, risk, time, and social costs. The model assumes that disruptions may have an impact on both the network link capacities as well as on the product demands. Two different cas...