Abstract 3-Aryloxindole derivatives were synthesized through a Friedel–Crafts-type cyclization. The reaction was catalyzed by trimethylsilyl tricyanopalladate complex generated in situ from cyanide and Pd(OAc)2. Wide varieties of diethyl phosphates derived N-arylmandelamides converted almost quantitatively into oxindoles. When N,N-dibenzylamide used instead an anilide substrate, benzo-fused δ-l...

The 5-HT7 receptor binding affinities of the oxindole derivatives have been quantitatively analyzed in terms of Dragon descriptors. The derived QSAR models have provided rationales to explain the binding affinity of titled compounds. In order to improve the 5-HT7 receptor binding affinity of a compound higher value of molecular topology and symmetry accounting parameter path/walk 2Randic shape ...

An efficient and highly stereoselective total synthesis of the natural product (+/-)-welwitindolinone A isonitrile (1) is described. The bicyclo[4.2.0]octane core of 1 was established by a regio- and diastereoselective [2+2] ketene cycloaddition. The C12 quaternary center and vicinal stereogenic chlorine were installed in a single operation with excellent stereocontrol via a chloronium ion medi...

A highly efficient and environmentally benign method for the synthesis of oxindoles featuring two contiguous quaternary carbon centers via an aldol reaction starting from various 3-substituted oxindoles has been established. A wide variety of such featured multi-substituted 1,3-indandione ring-fused 3-oxindole scaffolds were obtained smoothly in good yields (up to 98%) employing the most green ...

In the presence of chloroperoxidase, indole was oxidized by H2O2 to give oxindole as the major product. Under most conditions oxindole was the only product formed, and under optimal conditions the conversion was quantitative. This reaction displayed maximal activity at pH 4.6, although appreciable activity was observed throughout the entire pH range investigated, namely pH 2.5-6.0. Enzyme satur...

In metabolomics, the analysis of product ions in tandem mass spectrometry (MS/MS) is noteworthy to chemically assign structural information. However, the development of relevant analytical methods are less advanced. Here, we developed a method to boost sensitivity in liquid chromatography-Fourier transform ion cyclotron resonance-tandem mass spectrometry analysis (MS/MS boost analysis). To veri...

Abstract Objectives Presently, the pandemic of COVID-19 has worsened situation worldwide and received global attention. The United States America have highest numbers a patient infected by this disease followed Brazil, Russia, India many other countries. Moreover, lots research is going on to find out effective vaccines or medicine, but still, no potent vaccine drug discovered cure COVID-19. As...