BACKGROUND Chagas disease is caused by the protozoan Trypanosoma cruzi, which is transmitted to mammal hosts by triatomine insect vectors. The goal of this study was to model the spatial distribution of triatomine species in an endemic area. METHODS Vector's locations were obtained with a rural householders' survey. This information was combined with environmental data obtained from remote se...

From an epidemiological point of view, Chagas disease and its reservoirs and vectors can present the following characteristics: (i) enzooty, maintained by wild animals and vectors, with broad occurrence from southern United States of America (USA) to southern Argentina and Chile (42ºN 49ºS), (ii) anthropozoonosis, when man invades the wild ecotope and becomes infected with Trypanosoma cruzi fro...

The sustained expression of RNA-targeting Cas9 delivered intramuscularly or systemically by adeno-associated viral vectors eliminates pathogenic foci expanded-repeat transcripts and reverses muscle-disease phenotypes in mouse models myotonic dystrophy type 1.

Recent advancements in genetic and genome editing research, augmented by the discovery of new molecular tools such as CRISPR, have revolutionised field engineering enabling precise site-specific modifications with unprecedented ease. These technologies found a vast range applications, including development novel methods for control vector pest insects. According to their makeup engineering, the...