Design For Assembly/disassembly (DFA) allows systematic evaluations and analysis of product assembly and disassembly during the product design stage with the goal of reducing assembly costs, improving quality and shortening time to market. These evaluations include assemblability, disassemblability, part accessibility, and part layout [1]. With the growing availability and widespread use of hig...

The ductal epithelium plays a key role in physiological secretion of pancreatic enzymes into the digestive system. Loss of barrier properties of the pancreatic duct may contribute to the development of pancreatitis and metastatic dissemination of pancreatic tumors. Proinflammatory cytokines are essential mediators of pancreatic inflammation and tumor progression; however, their effects on the i...

The patterning of actin cytoskeleton structures in vivo is a product of spatially and temporally regulated polymer assembly balanced by polymer disassembly. While in recent years our understanding of actin assembly mechanisms has grown immensely, our knowledge of actin disassembly machinery and mechanisms has remained comparatively sparse. Saccharomyces cerevisiae is an ideal system to tackle t...

Designers and engineers need better tools methods to create highly repairable products. Design for disassembly reassembly is an important product related design feature that can enhance repair. In a product, the components fail most often should be easily accessible repair or replacement. This paper describes development of method visually map showing different routes towards target components....

Designing plastics for assembly and disassembly is essential to closing the resource loop

The rate of GTP hydrolysis by microtubules has been measured at tubulin subunit concentrations where microtubules undergo net disassembly. This was made possible by using microtubules stabilized against disassembly by reaction with ethylene glycol bis-(succinimidylsuccinate) (EGS) as sites for the addition of tubulin-GTP subunits. The tubulin subunit concentration was varied from 25 to 90% of t...

Epithelial cell-cell junctions are specialised structures connecting individual cells in epithelial tissues. They are dynamically and functionally linked to the actin cytoskeleton. Disassembly of these junctions is a key event during physiological and pathological processes, but how this influences gene expression is largely uncharacterised. Here, we investigate whether junction disassembly reg...

This report describes preliminary results of comparison disassembly calculations for a representative LMFBR model (2100i voided core) and arbitrary accident conditions. The analytic 1 methods employed were the computer programs: FX2-P00L, PAD,and VENUS-II. Calculations were performed at Argonne National Laboratory, Brigham Young University,and Los Alamos Scientific Laboratory. The calculated fi...