GPCRs catalyze GDP/GTP exchange in the α-subunit of heterotrimeric G proteins (Gαßγ) through displacement of the Gα C-terminal α5 helix, which directly connects the interface of the active receptor (R*) to the nucleotide binding pocket of G. Hydrogen-deuterium exchange mass spectrometry and kinetic analysis of R* catalysed G protein activation have suggested that displacement of α5 starts from ...

Existing methods of detecting explosives have many problems in terms of stability, sensitivity, high selectivity, and rapid sensing for any given situation. In this study, we selected a displacement method using a surface plasmon resonance (SPR) immunosensor, which is one of the ways to overcome these problems. In an SPR displacement immunoassay, the methods to realize a high sensitivity were i...

High-rise buildings subjected to lateral loads such as wind and earthquake loads must be checked not to exceed the limits on the maximum lateral displacement or the maximum inter-story drift ratios. In this paper, a sensing model for deformed shapes of a building structure in motion is presented. The deformed shape sensing model based on a 2D scanner consists of five modules: (1) module for acq...

Ecological character displacement occurs when competition imposes divergent selection on interacting species, causing divergence in traits associated with resource use. Generally, divergence is assumed to occur when selection acts on the same, continuously varying trait in both species. However, selection might target multiple traits, and even closely related heterospecifics involved in charact...

Deficits in the volume of the thalamus have been observed in both individuals with schizophrenia and their nonpsychotic relatives. However, no studies to date have examined the underlying pattern of thalamic shape change in relatives of individuals with schizophrenia. This study examined the volume and shape of the thalamus in schizophrenia subjects, their siblings, and healthy control individu...

A new method for manipulation of curves in several degrees is presented. When a point of curve is moved, it a ects a relative local segment, which size could depends of the propagation of the point through their lower resolution curves. So, for the same displacement of the point, could be generated relative local segments of di erent sizes, only varying a local parameter such sti ness constant....

The random midpoint displacement method is a widely applied algorithm used for terrain simulation. This paper first reviews the underlying theory and the algorithm of the random midpoint displacement method and then analyzes the characteristics of the simulated terrain. An implementation is developed for the successive random addition midpoint displacement method using the programming language ...

This paper presents a new way of determining the compatibility conditions for statically indeterminate trusses. It is based on equations relating the angular displacements (rotations) of truss elements to the corresponding extensions obtained by requiring the displacements of the truss structure to be compatible, i.e., single valued. This new angular displacement method is likely to be most adv...

introduction: it has been shown that joint click, an initial and common finding in internal derangement (id), respond to neither conservative treatment nor surgical intervention. this raises the question as to whether it must be treated in the absence of other pertinent signs and symptoms, so the aim of this study was to investigate and compare the mri findings of tmj in both normal subjects an...