INTRODUCTION Diabetes mellitus is associated with cardiovascular disease. Anti-diabetic therapy has a limited capability (if any) of changing the incidence of either death or major cardiovascular disease, and cardiovascular safety concerns have been raised. We aimed at identifying episodes of acute myocardial infarction associated to a relatively new class of drugs, dipeptidyl peptidase-4 inhib...

OBJECTIVE This updated meta-analysis determines the effect of dipeptidyl peptidase-4 inhibitors on glycemic and tolerability outcomes in patients with type 2 diabetes mellitus and chronic kidney disease with glomerular filtration rate of ⩽60 mL/min or on dialysis. METHODS In all, 14 citations were identified from multiple databases. Qualitative assessments and quantitative analyses were perfo...

Abstract Objective To provide the scientific basis for utility of rhizome Trillium govanianum as nutraceutical supplements in managing physiological glycemic levels. Methods The vitro enzyme inhibitory activity extract, fractions, and isolated steroidal saponins from part T. was carried out against ?-amylase, ?-glucosidase, dipeptidyl peptidase IV. molecular interactions, binding score, pharmac...

Natural chemical compounds from medicinal plants used for the healing of diseases and disorders with fewer side effects, easy accessibility economically cheap. The current study was aimed at finding novel drug like molecules as anti-diabetic using in silico approach. Intermolecular interactions between target proteins different antidiabetic were observed. Five phytocompounds selected Plumbago z...

Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members.