In the previous study, pickle-derived Lactiplantibacillus plantarum 22A-3 (LP22A3) suppressed ear edema in passive cutaneous anaphylaxis by its oral administration. Moreover, LP22A3 treatment directly to RBL-2H3 cells shows no effect on β-hexosaminidase release from but inhibited using Caco-2/RBL-2H3 co-culture system stimulated with apical side. this administration of decreased total IgE and o...

Atopic dermatitis (AD) is a common inflammatory skin disorder with complex pathogenesis, involving epidermal barrier dysfunction, microbiome abnormalities and type-2-skewed immune dysregulation. The signal transducer activator of transcription 3 (STAT3) factor which plays critical roles in variety biological processes. However, the role STAT3 keratinocytes AD remains unclear. In this study, we ...

All LMW respiratory allergens known to date can also induce skin allergy in test animals. The question here was if in turn skin allergens can induce allergy in the respiratory tract. Respiratory allergy was tested in Th2-prone Brown Norway (BN) rats by dermal sensitization with the contact allergen dinitrochlorobenzene (DNCB; 1%, day 0; 0.5%, day 7) and a head/nose-only inhalation challenge of ...

Though the effects of acupuncture in atopic dermatitis have been proven in clinical studies, its mechanism remains unclear. In this study, we investigate the effectiveness and mechanism of action for acupuncture treatment on the LI11 meridian point for treatment of allergic contact dermatitis. BALB/c mice received 1-chloro-2,4-dinitrobenzene (DNCB) application to induce skin inflammation. Acupu...

Nitrochlorobenzenes (NCBs) are very important in the chemical industry since they have been used as raw material for the manufacture of crop protection products, as active ingredients in the pharmaceutical industry, as pigments and as antioxidants as well as for other uses. In industrial processes, NCBs are produced by monochlorobenzene (MCB) nitration reactions and one of the main residuals fo...

Danggui Buxue Tang (DBT) is a herbal decoction that has been used in Chinese medicine to enhance qi and blood circulation. Previously, we found that DBT can suppress allergy-related asthma in mice, leading us to hypothesize that DBT might ameliorate allergy disease. In this study, we evaluated whether DBT can attenuate atopic dermatitis (AD) symptoms and have an anti-inflammatory effect on AD-l...

EGR1 encodes a transcription factor containing three zinc-finger (ZF) DNA-binding domains of the Cys2-His2 type. It is rapidly induced by variety extracellular stimuli and involved in multiple physiological processes, including apoptosis, cell proliferation, inflammation (Li et al., 2019Li T.T. Liu M.R. Pei D.S. Friend or foe, role EGR-1 cancer.Med Oncol. 2019; 37: 7Crossref PubMed Scopus (24) ...