A simplified method is described for the preparation of 14 alpha-hydroxymethyl-4,4-dimethyl-5 alpha-cholest-8-en-e beta-ol, 14 alpha-hydroxymethyl-4,4-dimethyl-5 alpha-cholest-7-en-3 beta-ol, and 14 alpha-hydroxymethyl-4,4-dimethyl-5-alpha-cholest-6-en-3 beta-ol from commercial lanosterol. This method represents a modification of the approach introduced by Fried and co-workers (Fried, J., J. W....

A 1H NMR study of histidine hydrochloride dissolved in water/dimethyl sulfoxide mixtures gives evidence that dimethyl sulfoxide is able to induce a proton transfer from the imidazolinium nitrogens (mainly N3) to the carboxylate group when its mole fraction becomes greater than 42%. The new tautomeric equilibrium AH2++- in equilibrium AH2+ is quantitatively studied as a function of the solvent c...

Bis[2-(4,6-dimethyl-pyrimidin-2-ylsulfan-yl)eth-yl]amine under hydro-thermal conditions has unexpectedly been transformed into the title compound, C(32)H(44)N(10)S(4). In the title mol-ecule, the zigzag 3,10-diaza-6,7-disulfanyldodecyl skeleton has two dimethyl-pyrimidinylsulfanyl groups at both ends, and the aza atoms each carry a dimethyl-pyrimidinyl unit. The N atoms in the skeleton show a p...

The aromas of cultivar Meeker red raspberry from Oregon and Washington were analyzed by aroma extract dilution analysis. Seventy-five aromas were identified [some tentatively (superscript T)] by mass spectrometry and gas chromatography-retention index; 53 were common to both, and 22 have not been previously reported in red raspberry. Twenty-one compounds had an equivalent odor impact in both: 2...

Epidermal growth factor, a potent mitogen, stimulates phosphorylation of its 170,000-dalton plasma membrane receptor. Dimethyl sulfoxide selectively increased phosphorylation of the epidermal growth factor receptor in rat liver microsomal fraction. Maximal stimulation occurred at 15 to 25 percent dimethyl sulfoxide and resembled the effect of epidermal growth factor in magnitude and rapidity. L...

The structure of the title compound (26DMPMA), C(11)H(15)NO, is closely related to the side-chain unsubstituted N-(2,6-dimethyl-phen-yl)acetamide and side-chain substituted N-(2,6-dimethyl-phen-yl)-2,2,2-trimethyl-acetamide and 2-chloro-N-(2,6-dimethyl-phen-yl)acetamide, with slightly different bond parameters. The mol-ecules in 26DMPMA are linked into chains through N-H⋯O hydrogen bonding.