background: glucantime ® is the first- line drug for the treatment of all forms of leishmaniasis. unfortunately, the prevalence of parasites becoming resistant to glucantime ® is increasing in several parts of the world including iran. as protein is the most important target for drugs in response to a variety of signals including drugs so, it seems expression protein patterns in sensitive and r...

A new method for the numerical modelling of physical phenomena described by nonlinear diffusion equations on a sphere is developed. The key point of the method is the splitting of the differential equation by coordinates that reduces the original 2D problem to a pair of 1D problems. Due to the splitting, while solving the 1D problems separately one from another we involve the procedure of map s...