The regulation of glutamine synthetase expression by dexamethasone was studied in rat skeletal muscles. Daily administration of dexamethasone caused striking enhancement of glutamine synthetase activity in plantaris, soleus, and diaphragm muscles. Northern blot analysis revealed that the dexamethasone-mediated increase of glutamine synthetase activity was associated with dramatically increased ...

The most devastating abiotic factors worldwide are drought and salinity, causing severe bottlenecks in the agricultural sector. To acclimatize to these harsh ecological conditions, plants have developed complex molecular mechanisms involving diverse gene families. Among them, S-adenosyl-L-methionine synthetase (SAMS) genes initiate physiological, morphological, changes enable adapt appropriatel...

Polymyxins are cationic lipopeptide antibiotics active against many species of Gram-negative bacteria. We sequenced the gene cluster for polymyxin biosynthesis from Paenibacillus polymyxa PKB1. The 40.8 kb gene cluster comprises three nonribosomal peptide synthetase-encoding genes and two ABC transporter-like genes. Disruption of a peptide synthetase gene abolished all antibiotic production, wh...

By inhibiting dihydropteroate synthetase and dihydrofolate reductase, sulfonamides and trimethoprim inhibit the synthesis of folate coenzymes and thereby affect the central pathway of the metabolism of C1 compounds (25). The sub-MIC of trimethoprim was shown to reduce the fimbriation, hemagglutination, and epithelial cell adhesion of several Escherichia coli strains (49, 55, 61) through the inh...

Although eliminating the pathogenic asexual stages of Plasmodium falciparum is pivotal for the successful treatment of individual symptomatic patients, at a population level reducing the carriage of viable gametocytes is crucial for limiting the transmission of malaria parasites. Gametocytes are the non-pathogenic sexual stages of the P. falciparum parasite responsible for transmission of the i...

Plasmodium falciparum is the main cause of human malaria and is one of the important pathogens causing high rates of morbidity and mortality. The total number of malaria patients in Vietnam has gradually decreased over the last decade. However, the spread of pathogens with drug resistance remains a significant problem. Defining the trend in genotypes related to drug resistance is essential for ...

In Gabon, sulfadoxine-pyrimethamine (SP) is recommended for intermittent preventive treatment during pregnancy (IPTp-SP) and for uncomplicated malaria treatment through ACTs drug. P. falciparum strains resistant to SP are frequent in areas where this drug is highly used and is associated with the occurrence of mutations on Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroa...