Junctophilin (JPH) proteins stabilize junctional membrane complexes between plasma membrane and endoplasmic reticulum, also implicated in some human diseases. JPH3 mutations are linked to Huntington's disease-like 2 syndrome. Through epigenomic study of a colon cancer cell line pair (HCT116 and DKO), we identified JPH3 as a methylated novel tumor suppressor gene (TSG) candidate at 16q24. We fur...

Digestive system malignancies are quite common, accounting for 25% of deaths from cancer in the European Union. Various etiological factors of carcinogenesis include hereditary mutations and susceptibility polymorphisms, inflammation due to infectious agents, environmental and dietary factors. Transgenic, knockout or mutant animal models are very useful in reproducing cancers of the digestive t...

studies undertaken during the last 5 years in the babol research station of the institute of public health research, teheran university, with the collaboration of the international agency for research on cancer in the caspian littoral and ardabil area in the north of iran has indicated the presence of cancer in 48 different sites. the five more prevalent types of cancer found in that area in or...

Aim of the Study: Despite the availability of high quality imaging modalities, 25-40% of patients who underwent a laparotomy for digestive cancer could not be resected, with non-resectability identified only during laparotomy. This prevalence is higher in developing countries due to lack of adequate radiographic devices. This study was undertaken to assess the value of diagnostic laparoscopy in...

Tumours of the digestive system include a number malignant tumours such as oesophageal, gastric and colorectal cancers, which have highest incidence mortality rates in world. Their occurrence is related to variety factors, diet, environment genetics. As key enzyme process folate metabolism, MTHFR gene polymorphism plays an important role pathogenesis development gastrointestinal tumours. This p...

background: gastric and colorectal adenocarcinoma are the second and the fifth most common cancers in iran, respectively. expression of cytokeratin 7 (ck7) is established in most malignancies including gastric and colorectal adenocarcinoma. demonstration of ck7 could be related to prognostic factors and help to the better management of the patients. the objective of our study was to evaluate th...

We report on key Digestive Disease Week sessions that focused on hepatitis C virus and Clostridium difficile infection, colonoscopy preparation, irritable bowel syndrome, and Crohn's disease. We also review major American Society of Clinical Oncology sessions on breast, pancreatic, ovarian, skin, and brain cancers and multiple myeloma.

Introduction: Cancer of the head pancreas is increasing in incidence. It represents 3% all cancers and 20% digestive cancers. Diagnosis most often late. Indeed, 80% these are discovered at an advanced stage. In this case, treatment essentially palliative. The reference chemotherapy associated with endoscopic if there obstruction bile duct. Palliative surgery only indicated case intraoper...

Objective: This study's aim was to examine the incidence and survival of cancer in Sivas between 2013-2019. Material Methods: In this retrospective cohort study, registry data were analysed. Age, sex, treatment types, definitive pathological diagnosis results, status patients questioned. Results: A total 7,946 people diagnosed with years examined 57.5% male. Systemically most common type digest...

OBJECTIVE Many studies have reported the prognostic predictive value of CD166 as a cancer stem cell marker in cancers of the digestive system; however, its predictive value remains controversial. Here, we investigate the correlation between CD166 positivity in digestive system cancers and clinicopathological features using meta-analysis. METHODS A comprehensive search in PubMed and ISI Web of...