BACKGROUND The loss of von Hippel-Lindau (VHL) protein function leads to highly vascular renal tumors characterized by an aggressive course of disease and refractoriness to chemotherapy and radiotherapy. Loss of VHL in renal tumors also differs from tumors of other organs in that the oncogenic cascade is mediated by an increase in the levels of hypoxia-inducible factor-2α (HIF2α) instead of hyp...

conclusions the pattern of pretreatment with o2 could change this potential and highly protective strategy against cp-induced nephropathy to an ineffective or even mildly deteriorating one. therefore, o2 administration before cp injection to patients with cancer, for therapeutic purposes or as a preconditioning approach, should be performed and investigated with caution until exact effects of d...

A man with metastatic carcinoma of the colon had a bone scan which revealed urinary retention in the left kidney. Ten months later, a Tc-99m-DTPA renai glomerular study showed the left kidney to have only 8% of total renal function. Fifteen months after that, (he same kidney demonstrated 9% of total function, while the right kidney had evolving obstruction due to his neoplasm. The case sh...

Objective(s):   This study aimed to address the gold nanoparticle(GNP)-dose and exposure duration effect on the kidney function of rats: in vivo.   Materials and Methods: A total of 32 healthy male Wistar rats were used in this study. Animals were randomly divided into groups, three GNP-treated groups and control group. Group 1, 2 and 3 received. /5 cc of solution containing 5, 10,100 ppm Au vi...

objective(s): this study aimed to develop drugs from natural sources to overcome the side effects of many of synthetic drugs. methanol extracts of both pericarp and seeds of pleiogynium solandri were used to investigate antioxidant, hepatoprotective, and renal function protective, analgesic, and anti-inflammatory effects and to determine the chemical composition of the extract responsible for b...

Nuclear medicine imaging is routinely used for evaluation of perfusion and function of the transplanted kidneys. At present, the radiopharmaceutical of choice for this study in our center is Tc 99m-Ec. Complications of the kidney graft are demonstrable in the early and delayed images. One of these complications is vesicoureteral reflux to the graft or to the native kidneys. We present a 27 year...

Radial Basis Functions (RBFs) have been found to be widely successful for the interpolation of scattered data over the last several decades. The numerical solution of nonlinear Partial Differential Equations (PDEs) plays a prominent role in numerical weather forecasting, and many other areas of physics, engineering, and biology. In this paper, Differential Quadrature (DQ) method- based RBFs are...

Ureteral endometriosis is a rare clinical condition in postmenopausal women. It should be considered as one of the differential diagnoses in women presenting with a lower ureteric mass, as it can lead to silent loss of renal function. We present a case of a chronically obstructed kidney due to ureteric endometriosis in a postmenopausal woman.

Renal angiotensinogen (ang-n) mRNA concentration in the male WKY rat increases significantly during puberty. Furthermore, renal angiotensinogen mRNA level in the adult female WKY rat is considerably lower than in the male. The present study investigates the role of androgen in differential renal ang-n mRNA expression. Northern and slot blot analyses with a-32P labeled ang-n cDNA (pRang 3) demon...