Intestinal alkaline phosphatase (IAP) is an essential mucosal defense factor involved in the process of maintenance gut homeostasis. We determined effect moderate exercise (voluntary wheel running) with or without treatment IAP on course experimental murine 2,4,6-trinitrobenzenesulfonic acid (TNBS) colitis by assessing disease activity index (DAI), colonic blood flow (CBF), plasma myokine irisi...

MODULATION OF ADIPOKINES BY N-3 POLYUNSATURATED FATTY ACIDS AND ENSUING CHANGES IN SKELETAL MUSCLE METABOLIC RESPONSE AND INFLAMMATION Justine Maye Tishinsky Advisor: University of Guelph, 2012 Dr. Lindsay E. Robinson Adipose tissue represents an important endocrine organ that secretes a multitude of adipokines known to mediate inflammation, lipid metabolism, and insulin sensitivity in peripher...

This study aimed to determine the gene expression of different local novel adipokines, such as vaspin, adiponectin, visfatin, and resistin, their known receptors, namely, heat shock 70 protein 5, adiponectin receptor 1, 2, in bovine corpus luteum (CL) during phases estrous cycle (on days 1–2, 3–4, 5–7, 8–12, 13–18, >18) pregnancy (at months >7). The mRNA was measured by reverse transcript...

BACKGROUND Adipose tissue functions as an endocrine organ by releasing adipokines which have important roles in the regulation of inflammation and insulin sensitivity. Although there is evidence of improvement in circulating levels of adipokines with weight loss, few studies relate such changes to specific diets. We investigated the effects of weight loss achieved by two different diets on circ...

OBJECTIVE To assess the effects of weight loss on adipokines, asthma-related symptoms, exercise-induced bronchospasm (EIB) and lung function, and to evaluate the role of leptin and adiponectin levels on lung function after treatment in obese adolescents. METHODS 84 postpubertal obese adolescents were enrolled and distributed in quartiles according to weight loss (low (<2.5 kg), low to moderat...

OBJECTIVE To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance. RESEARCH DESIGN AND METHODS In 1,176 South Asian, Chinese, Aboriginal, and European Canadians, fasting blood samples were drawn, and clinical history and dietary habits including glycemi...

Adipokines, factors produced by adipose tissue, may be proinflammatory (such as leptin and resistin) or anti-inflammatory (such as adiponectin). Effects of these adipokines on the lungs have the potential to evoke or exacerbate asthma. This review summarizes basic mechanistic data through population-based and clinical studies addressing the potential role of adipokines in asthma. Augmenting cir...

OBJECTIVE The potential insulin-sensitizing function of angiotensin II type 1 receptor blockade (ARB) with regard to selected adipokines is not fully explained so far. Our study aimed to explore the influence of acute hyperinsulinaemia and acutely induced ARB on resistin and adiponectin concentrations and expressions in healthy subjects. DESIGN AND METHODS Plasma adipokines were measured: 1) ...