This new Schiff base ligand (L) were prepared from condensation reaction of 3-amino-4-(1-methoxy-1-oxo-3-phenylpropan-2-ylamino)-4-oxo butanoic acid(aspartame) with 4-(dimethyl amino benzaldehyde). A series complexes divalent, trivalent and tetravalent ions prepared. The the cobalt, nickel, copper, palladium, platinum gold have been characterized by several techniques such as C.H.N.O, FT-IR, mo...

One of the most important targets in Alzheimer disease is Beta site amyloid precursor protein cleaving enzyme-1 (BACE-1). It is a membrane associated protein and is one of the main enzymes responsible for amyloid β (Aβ) production. Up to now, a considerable number of peptidic and non-peptidic inhibitors of BACE-1 have been developed. Recently, small molecule BACE-1 inhibitors have attracted the...

A novel azo-Schiff base ligand (L) was prepared by reacting 2-hydroxy-5-(pyridine-4-yldiazenyl) benzaldehyde with 1,2-phenylenediamine. Moreover, Silver nanoparticles (Ag-NPs) and Cadmium sulfide nanoparticles (CdS-NPs) were prepared by employing azo-Schiff base ligand (L) as capping and reducing agent. The solid-state fluorescence spectroscopy was used to investigate the interaction between L ...

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of TNF family, is an interesting ligand which selectively induces apoptosis in tumor cells and, therefore, it has been developed for cancer therapy. This ligand has been produced by various hosts such as E.coli. However, protein expression in E.coli cytoplasm leads to problems such as incorrect folding, reduction in biolo...

Three cis-chelating di-N-heterocyclic carbene palladium(II) complexes [Pd(X)2(di- NHC)] (X= tsac, sac and bit) tsac= thiosaccharinate, sac= saccharinate, bit= benzisothiazolinate, bearing different anionic co-ligand was synthesized characterized. A series of (2-5) homo-dicarbene ligand with varying propylene-bridged (C3) N-heterocyclic backbones (imidazole) have been by reaction [Pd(OAc)2] the ...

We report the first enantioselective addition of pyrazoles to 1,3-dienes. Secondary and tertiary allylic can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: Pd0-catalyzed ligand-to-ligand hydrogen transfer (LLHT). This hydroamination tolerates range functional groups advances field diene hydrofunctionalization.

The factors determining the catalytic performance of a recently discovered system for direct intermolecular alkyne hydroarylations, comprising gold(I) complex general formula LAuX (L = neutral ligand; X weakly coordinating counteranion) and an ionic liquid as solvent, have been investigated. In particular, effect anion, cation, electronic steric properties ligand L considered. results investiga...