BACKGROUND Cyclo-oxygenase-2 (COX-2) selective inhibitors have been associated with an increased risk of thrombotic cardiovascular events in placebo-controlled trials, but no clinical trial has been reported with the primary aim of assessing relative cardiovascular risk of these drugs compared with traditional non-steroidal anti-inflammatory drugs (NSAIDs). The MEDAL programme was designed to p...

BACKGROUND Current guidelines recommend that patients at risk for ulcer disease who require treatment for arthritis receive nonsteroidal antiinflammatory drugs (NSAIDs) that are selective for cyclooxygenase-2 or the combination of a nonselective NSAID with a proton-pump inhibitor. We assessed whether celecoxib would be similar to diclofenac plus omeprazole in reducing the risk of recurrent ulce...

The aim of this study was to compare the efficacy and safety of transdermal and oral routes of diclofenac for postoperative pain management in patients undergoing dental implant placement. Twenty systemically healthy, partially edentulous patients who required dental implants bilaterally in the mandibular first molar region were included. While the patient was under local anesthesia, an implant...

The present study was carried out to evaluate the adverse effects of a daily single injection of diclofenac sodium at different doses on some hematological, biochemical parameters and oxidative stress. Histological changes in liver and kidney induced by diclofenac sodium were also investigated in male albino rats. Forty five rats were randomly divided into 3 equal groups, the first group was gi...

Aims & Objectives: The present study was undertaken to compare the analgesic effect of Lornoxicam vis-à-vis diclofenac for postoperative pain relief in patients undergoing abdominal hysterectomy. Material & Methods: A total of 60 aduts patients having physical status grade I and II according to American Society of Anaesthesiologists (ASA) undergoing abdominal hysterectomy under general anaesthe...

In this research, we investigated the cytotoxic mechanisms of one of the widely used pharmaceuticals that are regularly associated with the adverse effects on the liver, sometimes leading to acute liver failure, diclofenac. Diclofenac liver cytotoxicity was associated with reactive oxygen species (ROS) formation and lipid peroxidation which were inhibited by antioxidants and ROS scavengers, fer...

Diclofenac has been conjugated with different antioxidants having antiulcerogenic activity with the objective of obtaining diclofenac-antioxidant mutual prodrugs as safer NSAIDs devoid of ulcerogenic side-effects. The synthesized derivatives are screened for their antiinflammatory, analgesic and antiulcer activity. The mutual prodrugs show retention of antiinflammatory activity with reduced ulc...

The hepatotoxic potential of diclofenac, a commonly used non-steroidal antiinflammatory agent, is well established in literature. However, cases diclofenacinduced liver disease have occurred almost exclusively with the oral formulation this medication. We report case an elderly man Paget’s and osteoarthritis who developed acute hepatotoxicity, as evidenced by laboratory diagnostics, four months...

This study explored the protective potential of apocyanin and curcumin in diclofenac-induced cardiotoxicity utilizing cardiac enzymes, pro-inflammatory markers, along with histopathological endpoints. A total 123 male Wistar rats were used for study. 43 determination median lethal dose (LD50) while 80 randomly divided into 8 groups 10 each. Group 1(control) received distilled water others orall...