Using an animal model of colonic inflammation, the effects of intrathecal (i.t.) diazepam (0.02 mg/kg, 0.08 mg/kg and 0.15 mg/kg) on visceral pain-related behaviors and hyperalgesia associated with colonic inflammation were investigated. In this visceral pain model, acute visceral pain response was induced by intracolonic (i.c.) injection of 0.5 ml of dilute formalin (2%, 5% and 10%) in rats, a...

1. After a fixed weight-related dose given intravenously, plasma diazepam concentrations were significantly lower in 11 cirrhotic patients than in controls matched for age and sex, in the 4 h after diazepam administration but not thereafter. 2. When measured at a single fixed time point, a greater proportion of the drug was in the unbound from in the plasma of cirrhotic patients, but non-bound ...

Bladder pain is a characteristic disorder of interstitial cystitis. Diazepam is well known for its antispasmodic activity in the treatment of muscular hypertonus. The aim of this work was to develop and characterize vaginal pessaries as an intravaginal delivery system of diazepam for the treatment of interstitial cystitis. In particular, the performance of two types of formulations, with and wi...

Interactions of GABA, bicuculline methochloride and diazepam with [3H]TBOB binding to rat brain membranes were evaluated in vitro. GABA displaced [3H]TBOB binding with and IC50 of 4 microM and a slope factor near unity. The competitive GABA antagonist bicuculline methochloride shifted the displacement curve of GABA parallelly to the right, indicating that the interaction of GABA with [3H]TBOB b...

OBJECTIVE To investigate pharmacological interactions of diazepam with non steroidal anti-inflammatory drugs. METHODS Non selective cyclooxygenase enzyme inhibitors (100 mg/kg acetylsalicylic acid, 10 mg/kg inhibitors (100 mg/kg acetylsalicylic acid, 10 mg/kg indomethacin, and 10 mg/kg diclofenac), a selective cyclooxygnase-1 inhibitor (10 mg/kg acetylsalicylic acid), and a selective cyclooxy...

SUZUKI, H. Effects of a Benzodiazepine Antagonist, Ro 15-1788, on Hippocampal Field Potentials in Freely Moving Rats. Tohoku J. Exp. Med., 1991, 165 (4), 261-270 Effects of a benzodiazepine receptor agonist (diazepam) and an antagonist (Ro 15-1788, flumazenil) administered separately or in combination on field potentials recorded from the hippocampal dentate area were examined in unanesthetized...

With the hypothesis that depression affects memory through a mechanism other than that of the benzodiazepines, the present study evaluated the acute effect of diazepam 10 mg upon explicit memory in patients with major depression. A double-blind, placebo (starch 50 mg) controlled experiment was carried out with 19 patients randomly divided into diazepam (n = 10) and placebo (n = 9) groups. They ...

background insomnia or sleeplessness is a disorder characterized by a personal incapability to falling or staying asleep for a desirable period of time, therefore disturb in quality of life. objectives the present study was carried out to investigate the effect of hydro-alcoholic extract of nepeta glomerulosa and its fractions on sleep-prolonging. materials and methods the extract and its fract...

how to cite this article : salehiomran mr, hoseini sm, ghabeli juibary a. intermittent diazepam versus continuous phenobarbital to prevent recurrence of febrile seizures: a randomized controlled trial. iran j child neurol. winter 2016;10(1):21-24. abstract objective febrile seizure is the most common neurologic problem in children between 3 months to 5 years old. two to five percent of children...