Cardiac performance was evaluated at least two years after doxorubicin treatment in childhood in 55 patients without overt congestive cardiomyopathy. None of the patients had received mediastinal irradiation. Computer-assisted analysis of digitised echocardiograms showed impaired rapid diastolic filling and an increased change of dimension between minimal cavity dimension and mitral valve openi...

Five red blood cell cation transport systems (RBCTS), together with blood lead level and blood pressure, were measured in 129 male adult subjects who were not occupationally exposed to lead or subsequent to a course of treatment for hypertension. Blood lead was positively related with systolic blood pressure, and to a lesser degree with diastolic blood pressure. Blood lead was found significant...

Preoperative and postoperative right heart catheterizations were performed on six patients with chronic constrictive pericarditis. Before surgery the patients characteristically showed distinct elevation of right ventricular end-diastolic, pulmonary arterial and wedge pressures. During the operation, right and left ventricular pressure curves were recorded both before and after pericardial rese...

Of seven patients with pulmonary hypertension, two had marked and one had moderate retardation of the echocardiographic anterior mitral valve leaflet closing motion, suggestive of mitral stenosis. In each patient, however, mitral stenosis was excluded by hemodynamic or anatomic criteria. The reason for the abnormal mitral valve motion was considered to be a reduced rate of left ventricular dias...

The left ventricular dimension and posterior wall dynamics were studied by computer assisted analysis ofM mode echocardiography in 25 normal children (group 1) and 32 transfusion dependent children with ,1 thalassaemia major who had no evidence of heart failure (group 2). Twenty seven of those in group 2 remained well but five died of cardiac decompensation within 12 months. Compared with group...

Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and oxidative stress markers were evaluated in 12-weeks female wild-type (WT group) and ob/ob mice (OB group). Results: OB animals showed increased body...

Background. Experimental studies indicate that in addition to diastolic dysfunction, hypertrophied myocardium can display depressed contractile responses, particularly at rapid heart rates, compounding reserve limitations. This study tests whether such abnormalities exist in intact human subjects at physiological paced rates and, if so, whether they are linked to simultaneous rate-dependent det...

Isolated diastolic dysfunction is found in almost half of asymptomatic patients with well-controlled diabetes and may precede diastolic heart failure. However, mechanisms that underlie diastolic dysfunction during diabetes are not well understood. We tested the hypothesis that isolated diastolic dysfunction is associated with impaired myocardial Ca(2+) handling during type 1 diabetes. Streptozo...

BACKGROUND The association between blood pressure (BP) and dementia is not easily interpreted, but some prospective studies suggest that dementia may lower BP. OBJECTIVE To examine the relationship between BP during a 10-year period and the prevalence of dementia. DESIGN Comparison of longitudinal BP between participants who had dementia, participants who were cognitively impaired, and unim...

Preoperative and postoperative right heart catheterizations were performed on six patients with chronic constrictive pericarditis. Before surgery the patients characteristically showed distinct elevation of right ventricular end-diastolic, pulmonary arterial and wedge pressures. During the operation, right and left ventricular pressure curves were recorded both before and after pericardial rese...