A fluxional bis-monodentate ligand, based on the archetypal shape-shifting molecule bullvalene, self-assembles with M2+ (M=Pd2+ or Pt2+) to produce a highly complex ensemble of permanently coordination cages. Metal-mediated self-assembly selects for an M2L4 architecture while maintaining ligand complexity. second level simplification is achieved guest-exchange; binding halides within cage mixtu...

The glucuronidation of 17beta-estradiol (beta-estradiol) and 17alpha-estradiol (epiestradiol) was studied to elucidate how the orientation of the 17-OH group affects conjugation at the 3-OH or the 17-OH of either diastereomer. Recombinant human UDP-glucuronosyltransferases (UGTs) UGT1A1, UGT1A3, UGT1A7, UGT1A8, and UGT1A10 conjugated one or both diastereomers, mainly at the 3-OH. The activity o...

The stereoselectivity and stereospecificity of the triflate-mediated intramolecular Schmidt reaction substituted 3-(1-azidocyclohexyl)propanol derivatives leading to octahydro-1H-pyrrolo[1,2-a]azepine, structural skeleton several important families alkaloids such as Stemona alkaloids, has been examined. involves an initial SN2 between azide moiety triflate affording intermediate spirocyclic ami...