Abstract High enantioselectivities (up to 99 %) and activities (TOF's up >4000 h −1 ) are accomplished in the Pd‐catalyzed allylic substitution of a wide range substrate types nucleophiles using family phosphite‐oxazoline ligands. These ligands were derived from PHOX ligand by exchanging phosphine moieties biaryl phosphites methylene spacer was introduced between oxazoline phenyl ring. The s...

The Front Cover shows the one-pot procedure for introduction of aminoalkyl chain through dialkyl carbonate chemistry into different phenolic substrates. This green approach is a direct alcohol substitution that avoids use chlorine giving CO2 and ethanol as only reaction by-products. proposed has numerous potential applications N,N-dialkyl ethylamine moieties are incorporated in many pharmacopho...

Some dialkyl alkylphosphonates and dialkyl phenylphosphonates were synthesized by the reactions between trialkyl phosphite and alkyl/aryl halide in the presence of benzene. The synthesized compounds were characterized by elemental analysis, thin layer chromatography (TLC), fourier –transform infrared, ( 1 H, 13 C) nuclear magnetic resonance (NMR) spectroscopic techniques. In vitro fungicidal ac...

Geometrically constrained dioxaphospholane rings were incorporated into a bis(phosphinimine)carbazole ligand (HL) in an effort to generate an ancillary ligand system that is capable of supporting reactive lutetium alkyl functionalities and resistant to cyclometalation reactivity. This new ligand was used to prepare a lutetium dialkyl species, LLu(CH2SiMe3)2; however, the complex exhibited low t...

The synthesis of the title compounds was carried out by reacting dicarboxylic acid chlorides with oximes in the presence of excess triethylamine. Disubstituted malonyl chlorides gave 2-alkenyl-4,4-dialkyl-3,5-isoxazolidinediones (8a-f) and 2,2'-ethylidene-bis[4,4-dialkyl-3,5-isoxazolidinedione]s (9a-f). Compounds 9 were formed from 8 and its N-unsubstituted 3,5-isoxazolidinedione decomposition ...

3-Sulfenyl- and 3-selenylindoles are readily synthesized by a two-step process involving the palladium/copper-catalyzed crossing coupling of N,N-dialkyl-ortho-iodoanilines and terminal alkynes and subsequent electrophilic cyclization of the resulting N,N-dialkyl-ortho-(1-alkynyl)anilines with arylsulfenyl chlorides or arylselenyl chlorides. The presence of a stoichiometric amount of n-Bu(4)NI i...

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 8 dialkyl sulfosuccinate salts for use in cosmetics, finding that these ingredients are safe in cosmetics in the present practices of use and concentration when formulated to be nonirritating. The dialkyl sulfosuccinate salts primarily function as surfactants in cosmetics. The Panel reviewed the new and existing av...

Mechanistic studies of the enolization of 2-methylcyclohexanone mediated by lithium hexamethyldisilazide (LiHMDS; TMS(2)NLi) solvated by hindered dialkyl ethers (ROR') are described. Rate studies using in situ IR spectroscopy show that enolizations in the presence of i-Pr(2)O, 2,2,5,5-tetramethyltetrahydrofuran, and cineole proceed via dimer-based transition structures [(TMS(2)NLi)(2)(ROR')(ket...

Six square planar Ni(II) complexes of 3,3-dialkyl/aryl-1-benzoylthiourea derivatives have been synthesized and characterized by elemental analyses, and electronic, FT-IR and NMR spectroscopic techniques. A cis-O2S2 disposition in complexes 3, 4 and 5 was confirmed by single crystal X-ray crystallography. The cytotoxicity of the 3,3-dialkyl/aryl-1-benzoylthiourea molecules and their complexes wa...