Introduction Early diagnosis of sepsis is the key for improving the survival, therefore biomarkers have an important place in this process because they can indicate the presence or absence of sepsis [1]. Procalcitonin aids in diagnosis and risk stratification of bacterial sepsis [2].Using pro-BNP as inflammatory marker in diagnosing severe sepsis and septic shock is based on cytokines productio...

Sepsis is a life-threatening condition that occurs when the body produces pro-inflammatory immune response to infection, leading decrease in blood flow results organ failure and death. has ability kill within hours, responsible for 20% of deaths globally. However, current diagnostic techniques pre-hospital setting are limited by time resources. It recently been found sepsis screening tools like...

Abstract In this commentary, we explored the advances made in miRNA and sepsis-induced acute lung injury (ALI) from perspective of diagnosis treatment. miRNAs play an important role ALI, including regulation inflammation, apoptosis, oxidative stress, thereby participating progression ALI. can act as therapeutic or diagnostic targets Also, development alternative inhibitory drugs targeting speci...

background and objectives: the aim of the study was to determine the role and characteristics of nosocomial and community acquired staphylococcus sepsis in admitted children in tertiary centers in iran. patients and methods: a cross sectional descriptive-analytic study was performed since march 2008 to march 2009 in which all blood cultures from various admitted patients were checked for staphy...

Early diagnosis of neonatal septicemia is difficult due to lack of specific clinical and laboratory findings. Blood culture is considered gold standard for the diagnosis, but is very time consuming. Hence most of the paediatricians administer antibiotics at the least suspicion of sepsis. To overcome this, several rapid haematological tests have been evaluated for their usefulness in rapid diagn...

Globally, an estimated 500,000 newborns die each year from serious neonatal infections, which account for about 15% of all neonatal deaths. “Suspected sepsis” is one of the most common reasons for admission to the neonatal intensive care unit (NICU). The challenge to the physician has always been trying to differentiate newborns with early onset sepsis from other non-infectious pathology whose ...

BACKGROUND Early onset bacterial sepsis is a feared complication of the newborn. A large proportion of infants admitted to the Neonatal Intensive Care Unit (NICU) for suspected sepsis receive treatment with potent systemic antibiotics while a diagnostic workup is in progress. The gold standard for detecting bacterial sepsis is blood culture. However, as pathogens in blood cultures are only dete...