plant growth regulators (pgrs) are widely used for lodging control in winter wheat (triticum aestivum l.) grown at high n rates. although the introduction of semi-dwarf wheat cultivars had largely solved the problem of lodging, evidence was already accumu-lating that the timely application of a growth retardant such as chlormequat (ccc) or ethephon could increase the grain yield of wheat, by th...

background & aim: the genus satureja belonging to the family of lamiaceae and consists of over 235 different species throughout the world. fourteen species grow naturally in iran of which eleven species are endemic. different species of satureja are used in food, healthy, cosmetic and medical industry. this reseach has been carried due to selection and introduction of suitable germplasm in ...

Coxsackievirus A16 (CA16) and enterovirus 71 (EV71), both of which can cause hand, foot and mouth disease (HFMD), are responsible for large epidemics in Asian and Pacific areas. Although inactivated EV71 vaccines have completed testing in phase III clinical trials in Mainland China, CA16 vaccines are still under development. A Vero cell-based inactivated CA16 vaccine was developed by our group....

Hypoallergenic antibacterial low-molecular-mass peptides were produced from defatted soybean meal in a membrane bioreactor. In the first step, soybean meal proteins were digested with trypsin in the bioreactor, operated in batch mode. For the tryptic digestion of soybean meal protein, optimum initial soybean meal concentration of 75 g/L, temperature of 40 °C and pH=9.0 were determined. After en...

The association efficiency of oxytetracycline (OTC) to pharmaceutical available, ionic oil-in-water nanoemulsions is studied. Theoretical mathematical developments allowed us to differentiate by diafiltration (DF) between thermodynamically and kinetically controlled binding of the drug to the nanoemulsions, and relate these important magnitudes to the association efficiency. The nanoemulsions h...

Recent advances in generating active proteins through refolding of bacterial inclusion body proteins are summarized in conjunction with a short overview on inclusion body isolation and solubilization procedures. In particular, the pros and cons of well-established robust refolding techniques such as direct dilution as well as less common ones such as diafiltration or chromatographic processes i...

The need for high-concentration formulations for subcutaneous delivery of therapeutic monoclonal antibodies (mAbs) can present manufacturability challenges for the final ultrafiltration/diafiltration (UF/DF) step. Viscosity levels and the propensity to aggregate are key considerations for high-concentration formulations. This work presents novel frameworks for deriving a set of manufacturabilit...

The clinical utility of cross-linked tetrameric hemoglobin solutions is limited by peripheral vasoconstriction thought to be due to scavenging of nitric oxide. In addition, transfusion of crude preparations of hemoglobin polymers can cause arterial hypertension. We tested the hypothesis that eliminating low-molecular-weight components from the polymer solution would prevent extravasation and it...

the aim of the present study was to estimate genetic and phenotypic parameters of milk production traits in the first and second lactations of romanian simmental dairy cattle. for the estimation of variance, heritability, genetic and phenotypic correlations among milk yield, fat yield, protein yield, and percentages of fat and protein, 3400 first and second lactation records over a period of fi...

Attaining maximum sustained yield (MSY) is a central goal in U.S. fisheries management. To attain MSY, fishing mortality is maintained at FMSY and biomass at BMSY. Replacing FMSY and BMSY by “proxies” for FMSY and BMSY is commonplace. However, these proxies are not equivalent to FMSY and BMSY. The lack of equivalency is an important issue with regard to whether MSY is attained or whether biomas...