OBJECTIVE Oxidative stress (OS) has been implicated in the aetiology and progression of diabetic complications including diabetic foot ulcer. In this study, the levels of lipid peroxides (LPO) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as well as the enzymatic antioxidant activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in type 2 diabetes mellitus and diabetic foot ulcer ...

We investigated the relationship between serum cystatin C levels and the prognosis of diabetic foot ulcerations (DFU). A population-based cohort study involving 1018 patients with type 2 diabetes was conducted. These patients recruited and divided into two groups: nondiabetic foot ulcer group (NDF, n = 865, 85.5%) and diabetic foot ulcer group (DFU, n = 147, 14.5%).After a 1-year-follow-up, DFU...

Background Diabetic foot complications are the most serious and costly problem of Diabetes Mellitus affecting substantially the quality of life of these patients. People with diabetic foot ulcers experience severe restrictions on daily life as a result of the ulcer. They face social isolation due to reduced mobility, they require frequent clinical treatment and constant caution to ensure that e...

Review of the clinical scenario You are a diabetes specialist nurse who, along with podiatrist colleagues, runs a foot care clinic for people with diabetes. A patient presents at the clinic with a full thickness plantar foot ulcer without any sign of arterial disease. The patient is enthusiastic to try an artificial skin replacement as she has read about them on the internet. You are unfamiliar...

OBJECTIVES Diabetic foot ulcer (DFU) is a common complication of diabetes and not only an important factor of mortality among patients with diabetes but also decreases the quality of life. The short form of Diabetic Foot Ulcer Scale (DFS-SF) provides comprehensive measurement of the impact of diabetic foot ulcers on patients' health related quality of life (HRQoL). The purpose of this study was...

Fifteen per cent of patients with diabetes will develop a foot ulcer in their lifetime. Foot complications (box 1) account for more hospital admissions than any other complication of diabetes, with considerable morbidity and mortality.1 People with diabetes are eight to 24 times more likely than those without diabetes to have a lower limb amputated.2 Around 85% of these amputations could be avo...

Review of the clinical scenario You are a diabetes specialist nurse who, along with podiatrist colleagues, runs a foot care clinic for people with diabetes. A patient presents at the clinic with a full thickness plantar foot ulcer without any sign of arterial disease. The patient is enthusiastic to try an artificial skin replacement as she has read about them on the internet. You are unfamiliar...

Background The inclusion of limited joint mobility (LJM) as a risk factor for plantar neuropathic foot ulceration in diabetes is interspersed throughout the literature. This is commonly believed to occur through connective tissue thickening and stiffening, thereby reducing available static and dynamic motion below that required for normal foot function. High underfoot pressures are postulated t...

IntroductionAmong Diabetes Mellitus (DM) patients, Diabetic Foot Ulcer (DFU) is the most prevalent complication that affects patients' quality of life (QoL). The present study aims to translate, validate, and test reliability Scale-Short Form (DFS-SF) in Malayalam language.MethodologyThe DFS-SF questionnaire was translated language using Mapi Research Trust translation guidelines. content valid...

Persons with diabetes mellitus (DM) and peripheral neuropathy are at high risk for skin breakdown due to unnoticed excessive pressures to the plantar foot during walking. We developed methods that combined spiral x-ray computed tomography (SXCT) imaging and plantar pressure analysis to quantify internal foot structure and external pressure during plantar loading. Methods were tested using a sub...