OpenDHT: A Public DHT Service

UDP-glucuronosyltransferase (UGT) 1A4-catalyzed glucuronidation is an important drug elimination pathway. Although atypical kinetic profiles (nonhyperbolic, non-Michaelis-Menten) of UGT1A4-catalyzed glucuronidation have been reported occasionally, systematic kinetic studies to explore the existence of multiple aglycone binding sites in UGT1A4 have not been conducted. To this end, two positional...

BACKGROUND Saussurea involucrata (Kar. et Kir.) (S. involucrate), is a rare traditional Chinese medicinal herb. Rutin and hispidulin as well as their metabolites are flavonoids of the flavonol type that abound in S. involucrata, which has been reported to inhibit nonoxidative advanced glycation end products which was involved in physiological inflammation. This study aims to investigate the rol...

The chemisorption and electrochemical activity of 2,5-dihydroxythiophenol (DHT) and 2-(8mercaptooctyl)-1,4-benzenediol (DHOT) on well-defined Pd(111) surfaces were studied by Auger electron spectroscopy (AES), low energy electron diffraction (LEED), high resolution electron energyloss spectroscopy (HREELS), and electrochemistry (EC). Results confirm that DHT is chemisorbed in two discrete orien...

OBJECTIVES The present study was aimed to evaluate the time-mannered and dose-dependent effects of 5α-dihydrotestosterone (5α-DHT) on the proliferation and differentiation of bone forming cells using MC3T3-E1 cells. MATERIALS AND METHODS Cell proliferation was analyzed using MTS and phase contrast microscopic assays. Osteogenic differentiation was assessed through a series of in vitro experim...

The role of central serotonergic neurons in circulatory control was studied in rabbits given intracisternal injections of 5,6-dihydroxytryptamine (5,6-DHT, 300 ̂ g/kg) to cause degeneration of central serotonergic nerve terminals and depletion of central serotonin stores. In normal rabbits, intracisternally administered 5,6-DHT produced decreases in mean arterial blood pressure (11%, P < 0.001) ...

We introduce the persistent homotopy type distance dHT to compare real valued functions defined on possibly different homotopy equivalent topological spaces. The underlying idea in the definition of dHT is to measure the minimal shift that is necessary to apply to one of the two functions in order that the sublevel sets of the two functions become homotopically equivalent. This distance is inte...